{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:40:03Z","timestamp":1782157203723,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,3,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To the authors' knowledge, it is unknown whether patient\u2010reported symptom severity and symptom interference with daily activities differ between younger (aged &lt;65 years) and older (aged \u226565 years) women receiving similar chemotherapy regimens for early breast cancer (EBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study participants rated 17 side effects of chemotherapy regimens currently in use in clinical practice (2014\u20102019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 284 women with EBC (stage I\u2010III), approximately 57% were aged &lt;65 years and 43% were aged \u226565 years. For anthracycline\u2010based regimens, a higher percentage of younger women reported moderate, severe, or very severe (MSVS) hot flashes (49% vs 18%) (<jats:italic>P<\/jats:italic> &lt; .001). For nonanthracycline regimens, a higher percentage of younger women reported MSVS hot flashes (38% vs 19%) (<jats:italic>P<\/jats:italic> = .009) and a lower percentage reported MSVS arthralgia (28% vs 49%) (<jats:italic>P<\/jats:italic> = .005). With regard to symptom interference with daily activities, a higher percentage of younger women being treated with anthracycline\u2010based regimens reported MSVS hot flashes (32% vs 7%) (<jats:italic>P<\/jats:italic> = .001) and myalgia (38% vs 18%) (<jats:italic>P<\/jats:italic> = .02). For nonanthracycline chemotherapy, a higher percentage of younger women reported MSVS interference for hot flashes (26% vs 9%) (<jats:italic>P<\/jats:italic> = .006) and lower percentages reported abdominal pain (13% vs 28%) (<jats:italic>P<\/jats:italic> = .02). Overall, there were no significant differences noted among younger versus older patients with regard to hospitalizations (19% vs 12%; <jats:italic>P<\/jats:italic> = .19), dose reductions (34% vs 31%; <jats:italic>P<\/jats:italic> = .50), dose delays (22% vs 25%; <jats:italic>P<\/jats:italic> = .59), or early treatment discontinuation (16% vs 16%; <jats:italic>P<\/jats:italic> = .9546).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older and younger women with EBC who were treated with identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom\u2010related interference with daily activities, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>In this study, women receiving chemotherapy for early breast cancer rated the severity of 17 symptoms and symptom interference with their activities of daily living.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Older (aged \u226565 years) and younger (aged &lt;65 years) women who received identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom\u2010related interference with daily activities, and adverse events.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33329","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T18:02:22Z","timestamp":1605895342000},"page":"957-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Patient\u2010reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2974-480X","authenticated-orcid":false,"given":"Kirsten A.","family":"Nyrop","sequence":"first","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Deal","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Tang","family":"Chen","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-8714","authenticated-orcid":false,"given":"Bryce B.","family":"Reeve","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-9318","authenticated-orcid":false,"given":"Ethan M.","family":"Basch","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit S.","family":"Shachar","sequence":"additional","affiliation":[{"name":"Rambam Health Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Carey","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-0177","authenticated-orcid":false,"given":"Katherine E.","family":"Reeder\u2010Hayes","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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