{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:34:15Z","timestamp":1788262455340,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2031130\u20101 (2020R1A2C2005091)"],"award-info":[{"award-number":["2031130\u20101 (2020R1A2C2005091)"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,5,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>By analyzing the recent epidemiologic trajectory of head and neck squamous cell carcinoma (HNSCC) in South Korea, we tracked 2 findings that have been reported recently in other countries: the stabilization of human papillomavirus (HPV)\u2010related HNSCC incidence and the acceleration of oral cavity cancer incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the comprehensive population\u2010based Korean Central Cancer Registry for the period 1999 to 2017. The age\u2010standardized incidence rate (ASR), annual percent change (APC), and relative survival were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ASR of total HNSCC decreased from 1999 to 2017 (APC, \u22120.2 [95% CI, \u22120.3 to \u22120.0]), as did the ASR of HPV\u2010unrelated HNSCC (APC, \u22120.6 [95% CI, \u22120.8 to \u22120.5]); however, the ASR of HPV\u2010related HNSCC increased (APC, 2.9 [95% CI, 2.5 to 3.2]). The rapidly increasing incidence of tonsil squamous cell carcinoma, which was the main subsite of HPV\u2010related HNSCC, stabilized after 2011 (APC pre\u20102011, 6.8 [95% CI, 5.0 to 8.3]; APC post\u20102011, 1.6 [95% CI, \u22122.1 to 5.5]), and the difference was significant (\n                      <jats:italic>P<\/jats:italic>\n                      = .017). In contrast, oral cavity cancer incidence demonstrated the only increase among HPV\u2010unrelated subsites, with the increase occurring after 2006 (APC pre\u20102006, 1.6 [95% CI, 0.3 to 2.8]; APC post\u20102006, 2.8 [95% CI, 2.2 to 3.5]); the main cause of this change was an increase in the ASR of tongue cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the recent stabilization of tonsil cancer incidence and the contrasting increase in oral cavity cancer incidence, unlike other HPV\u2010unrelated cancers. These trends require further surveillance and understanding in terms of tumor biology and prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.33434","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T09:09:25Z","timestamp":1613812165000},"page":"1638-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The emergence of oral cavity cancer and the stabilization of oropharyngeal cancer: Recent contrasting epidemics in the South Korean population"],"prefix":"10.1002","volume":"127","author":[{"given":"Yuh\u2010Seog","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-6015","authenticated-orcid":false,"given":"Jungirl","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seri","family":"Hong","sequence":"additional","affiliation":[{"name":"The Korea Central Cancer Registry National Cancer Center Goyang Republic of Korea"},{"name":"Division of Cancer Registration and Surveillance National Cancer Control Institute National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwan","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsun","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-9701","authenticated-orcid":false,"given":"Kyu\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"The Korea Central Cancer Registry National Cancer Center Goyang Republic of Korea"},{"name":"Division of Cancer Registration and Surveillance National Cancer Control Institute National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008918223334"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25767"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24243"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00370"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.016"},{"key":"e_1_2_9_10_1","volume-title":"SEER cancer statistics review, 1975\u20102015","author":"Noone AM","year":"2018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.7883"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20664"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2009.07.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.02.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25087"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.138"},{"key":"e_1_2_9_17_1","volume-title":"International classification of diseases for oncology (ICD\u2010O)","author":"Percy C","year":"1977"},{"key":"e_1_2_9_18_1","volume-title":"SEER summary staging manual\u20142000: codes and coding instructions","author":"Young JL","year":"2001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25699"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3733"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.006"},{"key":"e_1_2_9_22_1","unstructured":"National Cancer Institute.Joinpoint trend analysis software. Accessed August 14 2020.https:\/\/surveillance.cancer.gov\/joinpoint"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.49.Suppl_2.S3"},{"key":"e_1_2_9_24_1","unstructured":"International Agency for Research on Cancer World Health Organization.Cancer today: data visualization tools for exploring the global cancer burden in 2020. Accessed December 5 2020.https:\/\/gco.iarc.fr\/today"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.174"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1081"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939-019-1051-x"},{"key":"e_1_2_9_28_1","unstructured":"Korea Centers for Disease Control and Prevention.Korea health statistics 2018. Accessed December 9 2020.https:\/\/knhanes.cdc.go.kr\/knhanes\/sub04\/sub04_03.do?classType=7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24589"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3126\/nje.v6i4.17255"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1932"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.33434","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:46:34Z","timestamp":1760298394000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.33434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5,15]]}},"alternative-id":["10.1002\/cncr.33434"],"URL":"https:\/\/doi.org\/10.1002\/cncr.33434","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}