{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:42:17Z","timestamp":1787510537753,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA174976"],"award-info":[{"award-number":["R01 CA174976"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008435","name":"Abramson Family Cancer Research Institute","doi-asserted-by":"publisher","award":["Radiation Oncology Pilot Grant"],"award-info":[{"award-number":["Radiation Oncology Pilot Grant"]}],"id":[{"id":"10.13039\/100008435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","award":["Young Investigator's Award"],"award-info":[{"award-number":["Young Investigator's Award"]}],"id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. 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NFV was initiated 7 days before CRT and continued through CRT completion. Toxicity, radiographic responses, and pathologic responses were evaluated. Serial tumor biopsies (baseline, after NFV monotherapy, on NFV + CRT, and posttreatment) were evaluated by immunohistochemistry, NanoString, and reverse\u2010phase\u2010protein\u2010array analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NFV sensitized cervical cancer cells to radiation, increasing apoptosis and tumor suppression in vivo. Patients (n = 13) with International Federation of Gynecology and Obstetrics stage IIA through IVA squamous cell cervical carcinoma were enrolled, including 7 patients at DL1 and 6 patients at DL2. At DL1, expansion to 6 patients was required after a patient developed a dose\u2010limiting toxicity, whereas no dose\u2010limiting toxicities occurred at DL2. Therefore, DL2 was established as the recommended phase 2 dose. All patients at DL2 completed CRT, and 1 of 6 experienced grade 3 or 4 anemia, nausea, and diarrhea. One recurrence was noted at DL2, with disease outside the radiation field. Ten of 11 evaluable patients remained without evidence of disease at a median follow\u2010up of 50 months. NFV significantly decreased phosphorylated Akt levels in tumors. Cell cycle and cancer pathways also were reduced by NFV and CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NFV with CRT is well tolerated. The response rate is promising compared with historic controls in this patient population and warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.33449","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T05:26:31Z","timestamp":1619846791000},"page":"2279-2293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phase 1 trial of nelfinavir added to standard cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-4564","authenticated-orcid":false,"given":"Arlene E.","family":"Garcia\u2010Soto","sequence":"first","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami 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Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-2951","authenticated-orcid":false,"given":"Lorraine","family":"Portelance","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Hu","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph A.","family":"Lucci","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehman","family":"Qureshi","sequence":"additional","affiliation":[{"name":"The Wistar Institute Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-0418","authenticated-orcid":false,"given":"Andrew","family":"Kossenkov","sequence":"additional","affiliation":[{"name":"The Wistar Institute Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-9614","authenticated-orcid":false,"given":"Gordon B.","family":"Mills","sequence":"additional","affiliation":[{"name":"The Knight Cancer Institute Oregon 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