{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:20:55Z","timestamp":1783941655430,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA251654"],"award-info":[{"award-number":["K08CA251654"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Social support is crucial for successful recovery after hematopoietic stem cell transplantation (HSCT) and has the potential to affect patient quality of life (QOL) and health outcomes. However, there are limited data on the relationship between a patient's perception of his or her social support and these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a secondary analysis of 250 autologous and allogeneic HSCT recipients enrolled in 2 supportive care trials at Massachusetts General Hospital from April 2011 through February 2016. They assessed social support as a patient's perception of his or her social well\u2010being via the social well\u2010being subscale of the Functional Assessment of Cancer Therapy. The authors used multivariate regression analyses to examine the relationship between pretransplant social well\u2010being and QOL (Functional Assessment of Cancer Therapy\u2013Treatment Outcome Index), psychological distress (Hospital Anxiety and Depression Scale), posttraumatic stress disorder [PTSD] symptoms (PTSD Checklist), fatigue (Functional Assessment of Cancer Therapy\u2013Fatigue), and health care utilization (hospitalizations and days alive and out of the hospital) 6 months after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants were on average 56.4 years old (SD, 13.3 years); 44% (n = 110) and 56% (n = 140) received autologous and allogeneic HSCT, respectively. Greater pre\u2010HSCT social well\u2010being was associated with higher QOL (B = 0.10; 95% CI, 0.06\u20100.13; <jats:italic>P<\/jats:italic> &lt; .001), lower psychological distress (B = \u20130.21; 95% CI, \u20130.29 to \u20130.12; <jats:italic>P<\/jats:italic> &lt; .001), and lower PTSD symptoms (B = \u20130.12; 95% CI, \u20130.19 to \u20130.06; <jats:italic>P<\/jats:italic> &lt; .001). Pre\u2010HSCT social well\u2010being was not significantly associated with fatigue or health care utilization 6 months after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with higher pre\u2010HSCT perceptions of their social support reported better QOL and lower psychological distress 6 months after HSCT. These findings underscore the potential for social support as a modifiable target for future supportive care interventions to improve the QOL and care of HSCT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33455","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T10:07:52Z","timestamp":1613815672000},"page":"1260-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Sharing and caring: The impact of social support on quality of life and health outcomes in hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-9644","authenticated-orcid":false,"given":"Hermioni L.","family":"Amonoo","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital Boston Massachusetts"},{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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