{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:34:52Z","timestamp":1787697292523,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007137","name":"Texas Children's Hospital","doi-asserted-by":"publisher","award":["Internal Funding"],"award-info":[{"award-number":["Internal Funding"]}],"id":[{"id":"10.13039\/100007137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Sporadic optic pathway\/hypothalamic gliomas represent a unique entity within pediatric low\u2010grade glioma. Despite favorable survival, location makes treatment difficult and local progression debilitating. This study is a longitudinal assessment of visual acuity (VA) among children treated within the last 2 decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Clinical characteristics were abstracted for patients treated from 2000 to 2018 at Texas Children's Cancer Center in Houston. Ophthalmologic data taken at 3\u2010 to 6\u2010month intervals were examined with age\u2010appropriate VA metrics converted to the LogMAR (logarithm of the minimum angle of resolution) scale. Kaplan\u2010Meier blindness\u2010free survival (BFS) curves, calculated as time\u2010to\u2010bilateral functional blindness (LogMAR \u22650.8 in both eyes), were calculated for patients receiving early radiation therapy (RT; upfront or as first\u2010line salvage treatment) or chemotherapy (CT) and evaluated using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty\u2010eight patients with a median follow\u2010up of 8.5 years (range, 2\u201017 years) were identified. Median age at diagnosis was 3 years (interquartile range, &lt;1\u20106 years). Early RT was administered in 11 patients (29%). Twenty\u2010seven patients (71%) were treated primarily with CT, initiated at a median age of 3.5 years (range, &lt;1\u201011 years). Eight patients in the CT group did eventually require RT secondary to VA loss and following multiple lines of CT. Median age at RT for all patients was 11 years (range, 3\u201017 years). BFS rates were 81% at 5 years and 60% at 8 years for CT and 100% at 5 and 8 years for early RT (<jats:italic>P<\/jats:italic> = .017).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In a contemporary cohort, early RT, defined as initial or first\u2010line salvage therapy, was found to have superior BFS for appropriately selected patients with sporadic optic pathway\/hypothalamic gliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>LAY SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Children with low\u2010grade brain tumors of the optic pathway generally have excellent long\u2010term survival; however, given the location of these tumors, there can commonly be threatened vision if the tumor grows.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Although radiation is generally deferred in children on the basis of legitimate concerns regarding the effects on the developing brain, it may represent a vision\u2010preserving therapy for well\u2010selected older patients.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33497","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:13:22Z","timestamp":1616152402000},"page":"2358-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early radiotherapy preserves vision in sporadic optic pathway glioma"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-5057","authenticated-orcid":false,"given":"Alexander N.","family":"Hanania","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Dan L. Duncan Cancer Center Baylor College of Medicine Houston Texas"},{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-3045","authenticated-orcid":false,"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-5344","authenticated-orcid":false,"given":"Ethan B.","family":"Ludmir","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeral S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology Cincinnati Children's Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Su","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McGovern","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Frances","family":"McAleer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Grosshans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fatih","family":"Okcu","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali M.","family":"Chintagumpala","sequence":"additional","affiliation":[{"name":"Texas Children's Cancer Center Baylor College of Medicine Houston 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