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The effect of the treatment regimen (ICRT, CRT, and RT alone) was examined with mixed\u2010model analyses for the acute and late period. In the CRT cohort, the chemotherapy agent relationship with symptoms was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Chemoradiation (ICRT\/CRT) compared with RT alone resulted in significantly higher acute symptom scores in the majority of MDASI\u2010HN symptoms (ie, 21 out of 28). No late symptom differences between treatment with or without chemotherapy were observed that were not attributable to ICRT. Nausea was lower for CRT with carboplatin than for CRT with cisplatin; cetuximab was associated with particularly higher scores for acute and late skin, mucositis, and 6 other symptoms. The addition of ICRT compared with CRT or RT alone was associated with a significant increase in numbness and shortness of breath.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The addition of chemotherapy to definitive RT for OPC patients was associated with significantly worse acute symptom outcomes compared with RT alone, which seems to attenuate in the late posttreatment period. Moreover, induction chemotherapy was specifically associated with worse numbness and shortness of breath during and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>LAY SUMMARY<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Chemotherapy is frequently used in addition to radiotherapy cancer treatment, yet the (added) effect on treatment\u2010induced over time is not comprehensively investigated<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study shows that chemotherapy adds to the symptom severity reported by patients, especially during treatment<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33501","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T14:28:12Z","timestamp":1617200892000},"page":"2453-2464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of induction and\/or concurrent chemoradiotherapy on acute and late patient\u2010reported symptoms in oropharyngeal cancer: Application of a mixed\u2010model analysis of a prospective observational cohort registry"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-5616","authenticated-orcid":false,"given":"Lisanne V.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Radiation Oncology University Medical Center Groningen University of Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-7613","authenticated-orcid":false,"given":"Abdallah S. 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