{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T03:00:36Z","timestamp":1775358036685,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The use of haploidentical hematopoietic cell transplantation (haplo\u2010HCT) with posttransplantation cyclophosphamide prophylaxis is gaining traction in patients with acute lymphoblastic leukemia (ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The Acute Leukemia Working Party\/European Society for Blood and Marrow Transplantation registry was used to evaluate the outcomes of adult patients with ALL who underwent haplo\u2010HCT during 2011 through 2015 and compared them with the outcomes of those who underwent transplantation during 2016 through 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The analysis consisted of 195 patients, including 79 who underwent transplantation during 2011 through 2015 and 116 who underwent transplantation during 2016 through 2018. Overall, the 2\u2010year leukemia\u2010free survival and relapse incidence rates were 56.5% and 21%, respectively. The 100\u2010day incidence of grade 2 through 4 acute graft\u2010vs\u2010host disease (GVHD) was 34.5%. The rates of nonrelapse mortality (NRM) and overall survival (OS) were 22.5% and 64.7%, respectively. Patients who underwent transplantation during 2016 through 2018 experienced improved rates of leukemia\u2010free survival (64.9% vs 47.3%; <jats:italic>P<\/jats:italic> = .019) and OS (75.5% vs 53.5%; <jats:italic>P<\/jats:italic> = .006). Patients who underwent transplantation during 2016 through 2018 developed more grade 2 through 4 acute GVHD (42% vs 26.4%; <jats:italic>P<\/jats:italic> = .047). The incidence of relapse, GVHD\u2010free\/relapse\u2010free survival, grade 3 and 4 acute GVHD, chronic GVHD, and extensive chronic GVHD did not differ significantly between groups. In multivariate analysis, more recently transplanted patients had a significantly reduced risk of NRM (hazard ratio, 0.44; 95% CI, 0.22\u20100.89; <jats:italic>P<\/jats:italic> = .022) and improved OS (hazard ratio, 0.47; 95% CI, 0.26\u20100.86; <jats:italic>P<\/jats:italic> = .014). A comparable analysis of patients who had acute myeloid leukemia during the same timeframes did not reveal any statistically significant differences in any outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The outcome of adult patients with ALL who receive posttransplant cyclophosphamide has improved over time, with an impressive 2\u2010year OS of 75% and, most recently, an NRM rate of only 17%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33522","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:21:28Z","timestamp":1616152888000},"page":"2507-2514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcome of T\u2010cell\u2013replete haploidentical stem cell transplantation improves with time in adults with acute lymphoblastic leukemia: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"127","author":[{"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Hematology Division Sheba Medical Center Sackler Faculty of Medicine Tel Aviv University Ramat\u2010Gan Israel"},{"name":"European Society for Blood and Marrow Transplantation Acute Leukemia Working Party, St Anthony Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation Acute Leukemia Working Party, St Anthony Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yener","family":"Koc","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Medicana International Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Angelucci","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Unit IRCCS San Martino Hospital Polyclinic Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Tischer","sequence":"additional","affiliation":[{"name":"Medical Clinic III Grosshadern Clinic Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutlu","family":"Arat","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplant Unit Florence Nightingale Sisli Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Pioltelli","sequence":"additional","affiliation":[{"name":"Hematological Clinic of the University of Milano\u2010Bicocca San Gerardo Hospital Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Hematology Clinic IRCCS Foundation San Matteo Polyclinic Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[{"name":"Section of Hematology Department of Radiological and Hematological Sciences Catholic University of the Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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