{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:28:24Z","timestamp":1793179704698,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life\u2010threatening illness, isolating hospitalization, and substantial physical and psychological symptoms. However, data are limited regarding risk factors of posttraumatic stress disorder (PTSD) symptoms in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a secondary analysis of data from 160 patients with high\u2010risk AML who were enrolled in a supportive care trial. The PTSD Checklist\u2010Civilian Version was used to assess PTSD symptoms at 1 month after AML diagnosis. The Brief COPE and the Functional Assessment of Cancer Therapy\u2010Leukemia were to assess coping and quality of life (QOL), respectively. In addition, multivariate regression models were constructed to assess the relation between PTSD symptoms and baseline sociodemographic factors, coping, and QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty\u2010eight percent of patients reported PTSD symptoms, describing high rates of intrusion, avoidance, and hypervigiliance. Baseline sociodemographic factors significantly associated with PTSD symptoms were age (B = \u22120.26; <jats:italic>P<\/jats:italic> = .002), race (B = \u22128.78; <jats:italic>P<\/jats:italic> = .004), and postgraduate education (B = \u22126.30; <jats:italic>P<\/jats:italic> = .029). Higher baseline QOL (B = \u22120.37; <jats:italic>P<\/jats:italic> \u2264 .001) and less decline in QOL during hospitalization (B = \u22120.05; <jats:italic>P<\/jats:italic> = .224) were associated with fewer PTSD symptoms. Approach\u2010oriented coping (B = \u22120.92; <jats:italic>P<\/jats:italic> = .001) was associated with fewer PTSD symptoms, whereas avoidant coping (B = 2.42; <jats:italic>P<\/jats:italic> \u2264 .001) was associated with higher PTSD symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A substantial proportion of patients with AML report clinically significant PTSD symptoms 1 month after initiating intensive chemotherapy. Patients' baseline QOL, coping strategies, and extent of QOL decline during hospitalization emerge as important risk factors for PTSD, underscoring the need for supportive oncology interventions to reduce the risk of PTSD in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33524","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T09:23:08Z","timestamp":1616664188000},"page":"2500-2506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-9644","authenticated-orcid":false,"given":"Hermioni L.","family":"Amonoo","sequence":"first","affiliation":[{"name":"Department of Psychiatry Brigham and Women's Hospital Boston Massachusetts"},{"name":"Department of Psychosocial Oncology and Palliative Care Dana\u2010Farber Cancer Institute Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-7895","authenticated-orcid":false,"given":"Thomas W.","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Kavanaugh","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Division of Palliative Care Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Webb","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology Oregon Health and Science University Portland 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Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Elyze","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M.","family":"Longley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-6447","authenticated-orcid":false,"given":"Amir T.","family":"Fathi","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Department of Hematology Oncology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela S.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston 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