{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:09:17Z","timestamp":1788174557503,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The achievement of a 3\u2010month complete molecular response (CMR) is a major prognostic factor for survival in patients with Philadelphia chromosome (Ph)\u2010positive acute lymphoblastic leukemia (ALL). However, 25% of patients relapse during therapy with tyrosine kinase inhibitors (TKIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors reviewed 204 patients with Ph\u2010positive ALL who were treated between January 2001 and December 2018 using the combination of hyper\u2010CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone) plus a TKI (imatinib, 44 patients [22%]; dasatinib, 88 patients [43%]; or ponatinib, 72 patients [35%]). Progression\u2010free survival (PFS) was defined as the time from the start date of therapy to the date of relapse, death, or last follow\u2010up. Overall survival (OS) was defined as the time from the start date of therapy to the date of death or last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Overall, a 3\u2010month CMR was observed in 57% of patients, including 32% of those who received imatinib, 52% of those who received dasatinib, and 74% of those who received ponatinib. The median follow\u2010up was 74 months (imatinib, 180 months; dasatinib, 106 months; ponatinib, 43 months). Among 84 patients in 3\u2010month CMR, 17 (20%) proceeded to undergo allogeneic stem cell transplantation (ASCT). The 5\u2010year PFS and OS rates were 68% and 72%, respectively. By multivariate analysis, ponatinib therapy was the only significant favorable independent factor predicting for progression (\n                      <jats:italic>P<\/jats:italic>\n                      = .028; hazard ratio, 0.388; 95% CI, 0.166\u20100.904) and death (\n                      <jats:italic>P<\/jats:italic>\n                      = .042; hazard ratio, 0.379; 95% CI, 0.149\u20100.966). ASCT was not a prognostic factor for PFS and OS by univariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In patients with Ph\u2010positive ALL, ponatinib is superior to other types of TKIs in inducing and maintaining a CMR, thus preventing disease progression. ASCT does not improve outcome once a 3\u2010month CMR is achieved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.33529","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T17:08:04Z","timestamp":1617296884000},"page":"2648-2656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Prognostic factors for progression in patients with Philadelphia chromosome\u2010positive acute lymphoblastic leukemia in complete molecular response within 3 months of therapy with tyrosine kinase inhibitors"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-0610","authenticated-orcid":false,"given":"Koji","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston 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