{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:25:10Z","timestamp":1760315110273,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Although smoking has traditionally been the dominant causative factor of head and neck cancer, cancers of the tonsils and base of tongue increasingly are being driven by human papillomavirus, and these cancers are easier to cure.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>When radiation is used as the primary curative treatment, a number of studies have shown good outcomes with reduced doses of both radiation and chemotherapy.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>New techniques that access the tumor through the mouth instead of the jaw have made surgery dramatically less toxic. Outcomes are favorable, and many patients traditionally given radiation and chemotherapy afterward may be able to safely omit them.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33610","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T08:10:41Z","timestamp":1620461441000},"page":"3060-3063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgery alone for transorally resected human papillomavirus\u2013driven head and neck cancer\u2014can we de\u2010intensify adjuvant therapy to 0 Gy and 0 mg\/m<sup>2<\/sup>?"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4447","authenticated-orcid":false,"given":"Jared M.","family":"Weiss","sequence":"first","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01007"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29965"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.275"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33062"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.09.007"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30410-3"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.6500"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00463"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.8951"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.3300"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy522"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104957"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31526"},{"key":"e_1_2_4_15_1","article-title":"Oncologic outcomes of human papillomavirus\u2013associated oropharynx carcinoma treated with surgery alone: a 12\u2010institution study of 344 patients","volume":"127","author":"Ryan WR","year":"2021","journal-title":"Cancer"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.1166"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-6607-z"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.33610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:44:24Z","timestamp":1760262264000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.33610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,6]]},"references-count":16,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/cncr.33610"],"URL":"https:\/\/doi.org\/10.1002\/cncr.33610","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2021,5,6]]},"assertion":[{"value":"2021-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}