{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:52:01Z","timestamp":1789606321801,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["22987"],"award-info":[{"award-number":["22987"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Marked reductions in childhood cancer mortality occurred over the last decades in high\u2010income countries and, to a lesser degree, in middle\u2010income countries. This study aimed to monitor mortality trends in the Americas and Australasia, focusing on areas showing unsatisfactory trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age\u2010standardized mortality rates per 100,000 children (aged 0\u201014\u00a0years) from 1990 to 2017 (or the last available calendar year) were computed for all neoplasms and 8 leading childhood cancers in countries from the Americas and Australasia, using data from the World Health Organization database. A joinpoint regression was used to identify changes in slope of mortality trends for all neoplasms, leukemia, and neoplasms of the central nervous system (CNS) for major countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the last decades, childhood cancer mortality continued to decrease by approximately 2% to 3% per year in Australasian countries (ie, Japan, Korea, and Australia), by approximately 1.5% to 2% in North America and Chile, and 1% in Argentina. Other Latin American countries did not show any substantial decrease. Leukemia mortality declined in most countries, whereas less favorable trends were registered for CNS neoplasms, particularly in Latin America. Around 2016, death rates from all neoplasms were 4 to 6 per 100,000 boys and 3 to 4 per 100,000 girls in Latin America, and 2 to 3 per 100,000 boys and approximately 2 per 100,000 girls in North America and Australasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood cancer mortality trends declined steadily in North America and Australasia, whereas they were less favorable in most Latin American countries. Priority must be given to closing the gap by providing high\u2010quality care for all children with cancer worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Advances in childhood cancer management have substantially improved the burden of these neoplasms over the past 40\u00a0years, particularly in high\u2010income countries.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study aimed to monitor recent trends in America and Australasia using mortality data from the World Health Organization.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Trends in childhood cancer mortality continued to decline in high\u2010income countries by approximately 2% to 3% per year in Japan, Korea, and Australia, and 1% to 2% in North America.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Only a few Latin American countries showed favorable trends, including Argentina, Chile, and Mexico, whereas other countries with limited resources still lagged behind.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33642","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T16:40:29Z","timestamp":1622133629000},"page":"3445-3456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Childhood cancer mortality trends in the Americas and Australasia: An update to 2017"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-3923","authenticated-orcid":false,"given":"Matteo","family":"Malvezzi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-2714","authenticated-orcid":false,"given":"Gianfranco","family":"Alicandro","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Carioli","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Stony Brook Cancer Center Stony Brook University Stony Brook New York"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-5979","authenticated-orcid":false,"given":"Karina Braga","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Collective Health Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Pediatric Oncology Hospital Santa Marcelina\/TUCCA S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Services Research Centre for Primary Care and Public Health (Unisant\u00e9) University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-897X","authenticated-orcid":false,"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-0127","authenticated-orcid":false,"given":"Paola","family":"Bertuccio","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. 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