{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:19:05Z","timestamp":1791497945038,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Venetoclax (VEN) in combination with a hypomethylating agent (HMA) has become the standard of care for patients aged &gt;75 years and for those not eligible for intensive chemotherapy who have newly diagnosed acute myeloid leukemia (AML). The benefit of VEN\u2010based therapy in patients who have newly diagnosed AML with mutations in the <jats:italic>TP53<\/jats:italic> gene (<jats:italic>TP53<\/jats:italic><jats:sup>mut<\/jats:sup>) over standard therapy is undefined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010institutional, retrospective analysis, the authors assessed the clinical outcomes of 238 patients with newly diagnosed <jats:italic>TP53<\/jats:italic><jats:sup>mut<\/jats:sup> AML and compared the clinical characteristics, response to different therapies, and outcomes of those who received VEN\u2010based (n = 58) and non\u2013VEN\u2010based (n = 180) regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who received VEN\u2010based regimens were older (aged &gt;65 years: 81% vs 65%; <jats:italic>P<\/jats:italic> = .02) and had higher response rates (complete remission, 43% vs 32%; <jats:italic>P<\/jats:italic> = .06) than those who received non\u2013VEN\u2010based regimens. Compared with patients who received non\u2013VEN\u2010based regimens, no difference in overall survival (median, 6.6 vs 5.7 months; <jats:italic>P<\/jats:italic> = .4) or relapse\u2010free survival (median, 4.7 vs 3.5 months; <jats:italic>P<\/jats:italic> = .43) was observed in those who received VEN\u2010based regimens, regardless of age or intensity of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of VEN to standard treatment regimens did not improve outcomes in younger or older patients who had <jats:italic>TP53<\/jats:italic><jats:sup>mut<\/jats:sup> AML. These data highlight the need for novel therapies beyond VEN to improve the outcome of patients with <jats:italic>TP53<\/jats:italic><jats:sup>mut<\/jats:sup> AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33675","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T17:14:11Z","timestamp":1624900451000},"page":"3541-3551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Outcomes in patients with newly diagnosed <i>TP53<\/i>\u2010mutated acute myeloid leukemia with or without venetoclax\u2010based therapy"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-6415","authenticated-orcid":false,"given":"Sangeetha","family":"Venugopal","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston 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