{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:42:56Z","timestamp":1792064576239,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Five\u2010year relative survival for adolescent and young adult (AYA) patients with cancer diagnosed at the ages of 15 to 39 years is 85%. Survival rates vary considerably according to the cancer type. The purpose of this study was to analyze long\u2010term survival trends for cancer types with the highest mortality among AYAs to determine where the greatest burden is and to identify areas for future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Surveillance, Epidemiology, and End Results cancer registry and the National Center for Health Statistics, the authors examined the incidence, mortality, and survival for the 9 cancer types with the highest mortality rates in this age group from 1975 to 2016. JPSurv, new survival trend software, was used in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results suggested significant improvements in 5\u2010year relative survival for brain and other nervous system tumors, colon and rectum cancer, lung and bronchus cancer, acute myeloid leukemia, and non\u2010Hodgkin lymphoma (all <jats:italic>P<\/jats:italic> values &lt; .05). Limited or no improvement in survival was found for female breast cancer, cervical cancer, ovarian cancer, and bone and joint sarcomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Five\u2010year relative survival for multiple cancer types in AYAs has improved, but some common cancer types in this group still show limited survival improvements (eg, ovarian cancer). Survival improvements in colorectal cancer have been overshadowed by its rising incidence, which suggests a substantial disease burden. Future research should focus on female breast, bone, ovarian, and cervical cancers, which have seen minimal or no improvements in survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Survival trends for adolescents and young adults with cancer are presented from a 40\u2010year period.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Although survival progress is noted for brain cancer, lung cancer, acute myeloid leukemia, and colon and rectum cancer, the incidence of colon and rectum cancer remains high.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Minimal progress is evident for female breast, bone, ovarian, and cervical cancers, which are in need of renewed focus.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33793","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T03:01:35Z","timestamp":1627268495000},"page":"4277-4286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Survival outcomes for cancer types with the highest death rates for adolescents and young adults, 1975\u20102016"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-2958","authenticated-orcid":false,"given":"Denise Riedel","family":"Lewis","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-8359","authenticated-orcid":false,"given":"Elizabeth J.","family":"Siembida","sequence":"additional","affiliation":[{"name":"Center for Health Innovation and Outcomes Research Northwell Health Manhasset New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-7955","authenticated-orcid":false,"given":"Nita L.","family":"Seibel","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Detection National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Wilder","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela B.","family":"Mariotto","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cancer Stat Facts: Cancer Among Adolescents and Young Adults (AYAs) (Ages 15\u201039)","year":"2020"},{"key":"e_1_2_8_3_1","volume-title":"Adolescent and Young Adult Oncology Progress Review Group. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults With Cancer","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29870"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29869"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz031"},{"key":"e_1_2_8_8_1","volume-title":"SEER*Stat Software. Version 8.3.9","year":"2021"},{"key":"e_1_2_8_9_1","volume-title":"Surveillance, Epidemiology, and End Results Program. SEER*Stat Database: Mortality\u2014All COD, Aggregated Total U.S. (1990\u20102016) <Katrina\/Rita Population Adjustment>","year":"2018"},{"key":"e_1_2_8_10_1","volume-title":"Surveillance, Epidemiology, and End Results Program. SEER*Stat Database: Incidence\u2014SEER 21 Regs Limited\u2010Field Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2018 Sub (2000\u20102016), Katrina\/Rita Population Adjustment>\u2014Linked to County Attributes\u2014Total U.S., 1969\u20102017 Counties","year":"2019"},{"key":"e_1_2_8_11_1","volume-title":"JPSurv analysis tool"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-0423"},{"key":"e_1_2_8_13_1","volume-title":"Joinpoint trend analysis software. Version 3.5.1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01677.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101810"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30220"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25443"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2019.101094"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.10"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020890"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27089"},{"key":"e_1_2_8_23_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102017","author":"Howlader N","year":"2020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0723-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opx145"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12954"},{"key":"e_1_2_8_27_1","article-title":"Temozolomide for high grade glioma","volume":"4","author":"Hart MG","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26861"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2308"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208962"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2014.34.177"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916623"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntp014"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28749"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31100"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31136"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0273"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000238411.75324.59"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30739"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050518"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19130"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju289"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011115)92:10<2523::AID-CNCR1603>3.0.CO;2-6"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(03)00095-X"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0469"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11051"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.07.034"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142502"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5703"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010019\u20100816\u20100"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309675"},{"key":"e_1_2_8_53_1","first-page":"1","article-title":"Human papilloma vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"63","author":"Markowitz LE","year":"2014","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6832a3"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)30298\u20103"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833a0961"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.33793","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:20:57Z","timestamp":1760289657000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.33793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":55,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,11,15]]}},"alternative-id":["10.1002\/cncr.33793"],"URL":"https:\/\/doi.org\/10.1002\/cncr.33793","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"2021-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}