{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:37:46Z","timestamp":1789231066593,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH250201700006C"],"award-info":[{"award-number":["HHSH250201700006C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH250201700007C"],"award-info":[{"award-number":["HHSH250201700007C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014\u201020\u20101\u20102705"],"award-info":[{"award-number":["N00014\u201020\u20101\u20102705"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014\u201020\u20101\u20102832"],"award-info":[{"award-number":["N00014\u201020\u20101\u20102832"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Consolidative autologous hematopoietic stem cell transplantation (AHCT) is commonly used for patients with multiple myeloma (MM). We studied AHCT use and outcomes in patients with MM \u226575 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with MM \u226575 years old receiving AHCT between 2013 and 2017 in the United States were identified using the Center for International Blood and Marrow Transplant Research database. Relapse and\/or progression (REL), progression\u2010free survival (PFS), and overall survival (OS) were modeled using Cox proportional hazards models. Covariates used were age, sex, Karnofsky performance score (KPS), HCT\u2010comorbidity index (HCT\u2010CI), International Staging System and\/or Durie\u2010Salmon stage, high\u2010risk cytogenetics, melphalan dose, and disease status at and 1 year after transplant. AHCT utilization rate using the Surveillance, Epidemiology, and End Results database was used to estimate specific incidence among \u226575 years old by race and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 360 patients, 63% were male, 84% were White, 56% had KPS &lt;90, and 57% had HCT\u2010CI \u22653. The 100\u2010day transplant\u2010related mortality was 1% (0%\u20102%) with a 2\u2010year REL rate of 27% (95% confidence interval [CI], 22%\u201033%), PFS of 66% (95% CI, 60%\u201072%), and OS of 83% (95% CI, 78%\u201087%). On multivariate analysis, only high\u2010risk cytogenetics was associated with REL risk and decreased PFS. In White males, transplant utilization rate was 5.2%\u20105.8% compared to 3.5%\u20104.0% in African American males (<jats:italic>P<\/jats:italic> = .02). There was 3.37\u20103.79% transplant utilization in White females compared to 1.88\u20102.12% in African American females (<jats:italic>P<\/jats:italic> &lt; .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of AHCT was associated with excellent 2\u2010year outcomes in this selected MM population \u226575 years old. Transplant utilization for patients \u226575 years old remains low with significant racial and gender disparities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33831","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T07:02:02Z","timestamp":1628578922000},"page":"4233-4239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Outcomes of upfront autologous hematopoietic cell transplantation in patients with multiple myeloma who are 75 years old or older"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-9443","authenticated-orcid":false,"given":"Pashna N.","family":"Munshi","sequence":"first","affiliation":[{"name":"Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Vesole","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital Washington 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Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-2886","authenticated-orcid":false,"given":"Muzaffar","family":"Qazilbash","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-8173","authenticated-orcid":false,"given":"Nina","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology University of California\u2010San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswaran N.","family":"Hari","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-5643","authenticated-orcid":false,"given":"Anita","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"SEER data, 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