{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:44:17Z","timestamp":1787064257765,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID\u201019) and cancer are serious public health problems worldwide. However, little is known about the risk factors of in\u2010hospital mortality among COVID\u201019 patients with and without cancer in Brazil. The objective of this study was to evaluate the risk factors of in\u2010hospital mortality among COVID\u201019 patients with and without cancer and to compare mortality according to gender and topography during the year 2020 in Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a secondary data study of hospitalized adult patients with a diagnosis of COVID\u201019 by real\u2010time polymerase chain reaction testing in Brazil. The data were collected from the Influenza Epidemiological Surveillance Information System.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study analyzed data from 322,817 patients. The prevalence of cancer in patients with COVID\u201019 was 2.3%. COVID\u201019 patients with neurological diseases and cancer had the most lethal comorbidities in both sexes. COVID\u201019 patients with cancer were more likely to be older (median age, 67 vs 62 years;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), to have a longer hospital stay (13.1 vs 11.5 days;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), to be admitted to the intensive care unit (45.3% vs 39.6%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), to receive more invasive mechanical ventilation (27.1% vs 21.9%), and to have a higher risk of death (adjusted odds ratio [aOR], 1.94; 95% confidence interval [CI], 1.83\u20102.06;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) than those without cancer. Patients with hematological neoplasia (aOR, 2.85; 95% CI, 2.41\u20103.38;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) had a higher risk of mortality than those with solid tumors (aOR, 1.83; 95% CI, 1.72\u20101.95;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) in both sexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Brazilian COVID\u201019 patients with cancer have higher disease severity and a higher risk of mortality than those without cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.33832","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T14:44:37Z","timestamp":1628001877000},"page":"4240-4248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Higher severity and risk of in\u2010hospital mortality for COVID\u201019 patients with cancer during the year 2020 in Brazil: A countrywide analysis of secondary data"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3699-0590","authenticated-orcid":false,"given":"Guilherme Jorge","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Teaching and Research Pernambuco Cancer Hospital Recife Brazil"},{"name":"Department of Pneumology Instituto de Medicina Integral Professor Fernando Figueira Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-7002","authenticated-orcid":false,"given":"Carla Rameri Alexandre Silva","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Department of Oncology Instituto de Medicina Integral Professor Fernando Figueira Recife Brazil"},{"name":"Oncologia D'Or Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-2692","authenticated-orcid":false,"given":"Jos\u00e9 Iran Costa","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Oncology Instituto de Medicina Integral Professor Fernando Figueira Recife Brazil"},{"name":"Oncologia D'Or Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-8777","authenticated-orcid":false,"given":"Anke","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Brazilian National Cancer Institute (INCA) Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-6537","authenticated-orcid":false,"given":"Luiz Claudio Santos","family":"Thuler","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Brazilian National Cancer Institute (INCA) Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. 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