{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:21:05Z","timestamp":1784193665301,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["5T32CA094061"],"award-info":[{"award-number":["5T32CA094061"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["5UG1CA189974"],"award-info":[{"award-number":["5UG1CA189974"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adolescent and young adult (AYA) patients with cancer have not seen the same improvements in survival as younger (pediatric) patients and older patients (adults 40 years old or older). This may be related to their lower participation in clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study examined AYA patient accrual to SWOG Cancer Research Network phase 1 to 3 clinical treatment trials for 29 cancers over 25 years (January 1996 to December 2020). Trial enrollments for AYA patients (15\u201039 years old) were compared with trial enrollments for older patients (40 years old or older) in SWOG and with US AYA cancer population rates derived from US Census and National Cancer Institute\/Surveillance, Epidemiology, and End Results data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 84,219 patients were enrolled in SWOG treatment trials, including 7109 AYA patients (8.4%); in contrast, AYAs constituted 3.8% of the US cancer population. By histology, the highest proportions of AYA patients were in trials for Hodgkin disease (825 of 1220; 67.6%) and acute lymphocytic leukemia (350 of 678; 51.6%), whereas breast cancer trials had the greatest number of AYA patients (3032 of 32,693; 9.3%). SWOG AYA patients were more often female (68.8% vs 58.7%; <jats:italic>P<\/jats:italic> &lt; .001), Black (10.1% vs 8.2%; <jats:italic>P<\/jats:italic> &lt; .001), and Hispanic (10.6% vs 5.6%; <jats:italic>P<\/jats:italic> &lt; .001) than SWOG patients who were 40 years old or older, and they were more often female (68.8% vs 65.1%; <jats:italic>P<\/jats:italic> &lt; .001) but less often Black (10.1% vs 11.8%; <jats:italic>P<\/jats:italic> &lt; .001) or Hispanic (10.6% vs 12.8%; <jats:italic>P<\/jats:italic> &lt; .001) than AYA patients in the US cancer population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AYA patients with cancer were well represented in SWOG clinical trials in comparison with US cancer population patients with the same cancers. The SWOG AYA population was more racially\/ethnically diverse than older SWOG patients, although it was less diverse than the US AYA cancer population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Adolescent and young adult (AYA) patients with cancer (aged 15\u201039 years) have not seen the same improvements in survival as younger (pediatric) patients and older patients (adults 40 years old or older). This may be related to their lower participation in clinical trials.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study evaluated the extent to which AYA patients were enrolled in a large, National Cancer Institute\u2013sponsored network group over 25 years (1996\u20102020).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Overall, 8.4% of the enrolled patients (7109 of 84,219) were AYAs; this was twice the corresponding rate of 3.8% in the US cancer population.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>AYA patients were also more racially\/ethnically diverse than older trial patients, although they were less racially\/ethnically diverse than the US AYA cancer population.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33855","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T10:29:49Z","timestamp":1628159389000},"page":"4574-4584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Adolescent and young adult enrollment to a National Cancer Institute\u2013sponsored National Clinical Trials Network Research Group over 25 years"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5191-0317","authenticated-orcid":false,"given":"Joseph M.","family":"Unger","sequence":"first","affiliation":[{"name":"SWOG Statistics and Data Management Center Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Beauchemin","sequence":"additional","affiliation":[{"name":"Mailman School of Public Health 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