{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:29:46Z","timestamp":1784946586526,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR001874"],"award-info":[{"award-number":["KL2TR001874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hodgkin lymphoma (HL) is a treatable tumor affecting children, adolescents and young adults (AYAs; 15\u201039 years old). Population\u2010based studies report worse survival for non\u2010White children and AYAs but have limited data on individual therapeutic exposures. This study examined overall and HL\u2010specific survival in a population\u2010based cohort of patients while adjusting for sociodemographic factors and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data for 4807 patients younger than 40 years with HL (2007\u20102017) were obtained from the California Cancer Registry. Individual treatment information was extracted from text fields; chemotherapy regimens were defined by standard approaches for pediatric and adult HL. Multivariable Cox models examined the influence of patient and treatment factors on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up of 4.4 years, 95% of the patients were alive. Chemotherapy differed by age, with 70% of 22\u2010 to 39\u2010year\u2010olds and 41% of &lt;22\u2010year\u2010olds receiving doxorubicin, bleomycin, vinblastine, and dacarbazine (<jats:italic>P<\/jats:italic> &lt; .001). In multivariable models, older patients (22\u201039 vs &lt; 21 y; hazard ratio [HR], 1.53; 95% confidence interval [CI], 1.11\u20102.10), Black (vs White patients); HR, 1.90; 95% CI, 1.25\u20102.88), and Hispanic patients (HR, 1.45; 95% CI, 1.06\u20101.99) experienced worse survival; among those &lt; 21 y, Black race was associated with a 3.3\u2010fold increased risk of death (HR, 3.26; 95% CI, 1.43\u20107.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children and AYAs with HL, older age and non\u2010White race\/ethnicity predicted worse survival after adjustments for treatment data. Further work is needed to identify the biological and nonbiological factors driving disparities in these at\u2010risk populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33868","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T05:00:35Z","timestamp":1631077235000},"page":"4613-4619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Initial cancer treatment and survival in children, adolescents, and young adults with Hodgkin lymphoma: A population\u2010based study"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-6754","authenticated-orcid":false,"given":"Justine M.","family":"Kahn","sequence":"first","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-6229","authenticated-orcid":false,"given":"Frances B.","family":"Maguire","sequence":"additional","affiliation":[{"name":"California Cancer Reporting and Epidemiologic Surveillance Program University of California Davis Comprehensive Cancer Center Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training and Division of Hematology and Oncology University of California Davis School of Medicine Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Abrah\u00e3o","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training and Division of Hematology and Oncology University of California Davis School of Medicine Sacramento California"},{"name":"Center for Healthcare Policy and Research University of California Davis School of Medicine Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E.","family":"Flerlage","sequence":"additional","affiliation":[{"name":"Center for Healthcare Policy and Research University of California Davis School of Medicine Sacramento California"},{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-2848","authenticated-orcid":false,"given":"Elysia","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training and Division of Hematology and Oncology University of California Davis School of Medicine Sacramento California"},{"name":"Department of Pediatrics University of California Davis School of Medicine Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-4008","authenticated-orcid":false,"given":"Theresa H. 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