{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:17:57Z","timestamp":1787883477879,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Solid organ transplant recipients have an elevated risk of cancer. Quantifying the life\u2010years lost (LYL) due to cancer provides a complementary view of the burden of cancer distinct from other metrics and may identify subgroups of transplant recipients who are most affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Linked transplant and cancer registry data were used to identify incident cancers and deaths among solid organ transplant recipients in the United States (1987\u20102014). Data on LYL due to cancer within 10 years posttransplant were derived using mean survival estimates from Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 221,962 transplant recipients, 13,074 (5.9%) developed cancer within 10 years of transplantation. During this period, the mean LYL due to cancer were 0.16 years per transplant recipient and 2.7 years per cancer case. Cancer was responsible for a loss of 1.9% of the total life\u2010years expected in the absence of cancer in this population. Lung recipients had the highest proportion of total LYL due to cancer (0.45%) followed by heart recipients (0.29%). LYL due to cancer increased with age, from 0.5% among those aged birth to 34 years at transplant to 3.2% among those aged 50 years and older. Among recipients overall, lung cancer was the largest contributor, accounting for 24% of all LYL due to cancer, and non\u2010Hodgkin lymphoma had the next highest contribution (15%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transplant recipients have a shortened lifespan after developing cancer. Lung cancer and non\u2010Hodgkin lymphoma contribute strongly to LYL due to cancer within the first 10 years after transplant, highlighting opportunities to reduce cancer mortality through prevention and screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33877","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T03:02:34Z","timestamp":1632106954000},"page":"150-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Life\u2010years lost due to cancer among solid organ transplant recipients in the United States, 1987 to 2014"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6997-4004","authenticated-orcid":false,"given":"Anne\u2010Michelle","family":"Noone","sequence":"first","affiliation":[{"name":"Divison of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Divison of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Schaubel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne F.","family":"Dorgan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Magder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland Baltimore Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyllene R.","family":"Morris","sequence":"additional","affiliation":[{"name":"Institute for Population Health Improvement UC Davis Health System Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Pawlish","sequence":"additional","affiliation":[{"name":"New Jersey Department of Health Cancer Epidemiology Services Trenton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Engels","sequence":"additional","affiliation":[{"name":"Divison of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1592"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61050\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102\u2010991"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13862"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13549"},{"key":"e_1_2_8_7_1","volume-title":"OPTN\/SRTR 2003 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients","author":"Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation","year":"2003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02177.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199007000-00012"},{"key":"e_1_2_8_12_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102013","author":"Howlader N","year":"2016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2017.303986"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201020\u20100782"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2009.02571.x"},{"key":"e_1_2_8_16_1","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results Program.Incidence Site Recode Variables. 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