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Although nausea and vomiting are commonly grouped together, research has shown that antiemetics are clinically effective against chemotherapy\u2010induced vomiting (CIV) but less so against chemotherapy\u2010induced nausea (CIN). Nausea remains a problem for up to 68% of patients who are prescribed guideline\u2010consistent antiemetics. Despite the high prevalence of CIN, relatively little is known regarding its etiology independent of CIV. This review summarizes a metagenomics approach to the study and treatment of CIN with the goal of encouraging future research. Metagenomics focuses on genetic risk factors and encompasses both human (ie, host) and gut microbial genetic variation. Little work to date has focused on metagenomics as a putative biological mechanism of CIN. Metagenomics has the potential to be a powerful tool in advancing scientific understanding of CIN by identifying new biological pathways and intervention targets. 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