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Linear regression was used to model outcomes on baseline symptoms, treatment, and other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants (n = 458) in both treatment arms reported greater fatigue and endocrine symptoms at early follow\u2010up in comparison with the baseline. The magnitude of change in fatigue was significantly greater for the CT+E arm than the E arm at 3 and 6 months but not at 12, 24, or 36 months. The CT+E arm reported significantly greater changes in endocrine symptoms from the baseline to 3 months in comparison with the E arm; change scores were not significantly different at later time points. Endocrine symptom trajectories by treatment differed by menopausal status, with the effect larger and increasing for postmenopausal patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjuvant CT+E was associated with greater increases in fatigue and endocrine symptoms at early time points in comparison with E. These differences lessened over time, and this demonstrated early chemotherapy effects more than long\u2010term ones. Treatment arm differences in endocrine symptoms were more evident in postmenopausal patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Participants in TAILORx (Trial Assigning Individualized Options for Treatment) with early\u2010stage hormone receptor\u2013positive breast cancer and an intermediate risk of recurrence were randomly assigned to endocrine or chemoendocrine therapy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Four hundred fifty\u2010eight women reported fatigue and endocrine symptoms at the baseline and at 3, 6, 12, 24, and 36 months.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Both groups reported greater symptoms at early follow\u2010up versus the baseline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Increases in fatigue were greater for the chemoendocrine group than the endocrine group at 3 and 6 months but not later.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The chemoendocrine group reported greater changes in endocrine symptoms in comparison with the endocrine group at 3 months but not later.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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