{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:28:52Z","timestamp":1790116132093,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["136791"],"award-info":[{"award-number":["136791"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphedema is a prevalent long\u2010term effect of breast cancer treatment associated with reduced quality of life. This study examined the efficacy of nighttime compression as a self\u2010management strategy for women with chronic breast cancer\u2013related lymphedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Th authors conducted a parallel 3\u2010arm, multicenter, randomized trial. Women were recruited from 3 centers in Canada and randomized to group 1 (daytime compression garment alone [standard care]), group 2 (daytime compression garment plus nighttime compression bandaging), or group 3 (daytime compression garment plus the use of a nighttime compression system garment). The primary outcome was the change in excess arm volume from the baseline to 12\u00a0weeks. Participants from all groups used a nighttime compression system garment from weeks 13 to 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty women were enrolled, 118 completed the randomized trial, and 114 completed the 24\u2010week follow\u2010up. The rates of adherence to nighttime compression were 95%\u00a0\u00b1\u00a015% and 96%\u00a0\u00b1\u00a011% in the compression bandaging and nighttime compression system groups, respectively. After the intervention, the addition of nighttime compression was found to be superior to standard care for both absolute milliliter reductions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) and percentage reductions (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) in excess arm lymphedema volume. Significant within\u2010group changes were seen for quality of life across all groups; however, no between\u2010group differences were found (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The trial demonstrated a significant improvement in arm lymphedema volume from the addition of nighttime compression whether through the application of compression bandaging or through the use of a nighttime compression system garment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Lymphedema is swelling that occurs in the arm on the side of the surgery for breast cancer.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Lymphedema occurs in approximately 21% of women.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Lymphedema tends to worsen over time and can result in recurrent infections in the arm, functional impairment, and pain.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Currently, treatment consists of intensive treatments to reduce the swelling followed by regular use of a compression sleeve during the day.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study examined and found a benefit from the addition of nighttime compression (whether through self\u2010applied compression bandaging or through the use of a nighttime compression system garment) to the use of a daytime compression sleeve.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.33943","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T18:22:36Z","timestamp":1633717356000},"page":"587-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Nighttime compression supports improved self\u2010management of breast cancer\u2013related lymphedema: A multicenter randomized controlled trial"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-4847","authenticated-orcid":false,"given":"Margaret L.","family":"McNeely","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Alberta Edmonton Alberta Canada"},{"name":"Cross Cancer Institute Alberta Health Services Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi D.","family":"Dolgoy","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolette Skjodt","family":"Rafn","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute Alberta Health Services Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Ospina","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M.","family":"Al Onazi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Radke","sequence":"additional","affiliation":[{"name":"Tom Baker Cancer Centre Alberta Health Service Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Shular","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute Alberta Health Services Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urve","family":"Kuusk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Webster","sequence":"additional","affiliation":[{"name":"Tom Baker Cancer Centre Alberta Health Service Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-1382","authenticated-orcid":false,"given":"Kristin L.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute Alberta Health Services Edmonton Alberta 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