{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:19Z","timestamp":1787500519495,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA21765"],"award-info":[{"award-number":["P30 CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA211996"],"award-info":[{"award-number":["R01 CA211996"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10 CA095861"],"award-info":[{"award-number":["U10 CA095861"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10 CA098413"],"award-info":[{"award-number":["U10 CA098413"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10 CA098543"],"award-info":[{"award-number":["U10 CA098543"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10 CA180886"],"award-info":[{"award-number":["U10 CA180886"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10 CA180899"],"award-info":[{"award-number":["U10 CA180899"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U24 CA55727"],"award-info":[{"award-number":["U24 CA55727"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1 CA189955"],"award-info":[{"award-number":["UG1 CA189955"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6243\u201013"],"award-info":[{"award-number":["6243\u201013"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to examine long\u2010term outcomes among children newly diagnosed with cancer who were treated in dexrazoxane\u2010containing clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>P9404 (acute lymphoblastic leukemia\/lymphoma [ALL]), P9425 and P9426 (Hodgkin lymphoma), P9754 (osteosarcoma), and Dana\u2010Farber Cancer Institute 95\u201001 (ALL) enrolled 1308 patients between 1996 and 2001: 1066 were randomized (1:1) to doxorubicin with or without dexrazoxane, and 242 (from P9754) were nonrandomly assigned to receive dexrazoxane. Trial data were linked with the National Death Index, the Organ Procurement and Transplantation Network, the Pediatric Health Information System (PHIS), and Medicaid. Osteosarcoma survivors from the Childhood Cancer Survivor Study (CCSS; n\u00a0=\u00a0495; no dexrazoxane) served as comparators in subanalyses. Follow\u2010up events were assessed with cumulative incidence, Cox regression, and Fine\u2010Gray methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In randomized trials (cumulative prescribed doxorubicin dose, 100\u2010360\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; median follow\u2010up, 18.6\u00a0years), dexrazoxane was not associated with relapse (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.63\u20101.13), second cancers (HR, 1.19; 95% CI, 0.62\u20102.30), all\u2010cause mortality (HR, 1.07; 95% CI, 0.78\u20101.47), or cardiovascular mortality (HR, 1.45; 95% CI, 0.41\u20105.16). Among P9754 patients (all exposed to dexrazoxane; cumulative doxorubicin, 450\u2010600\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; median follow\u2010up, 16.6\u201018.4\u00a0years), no cardiovascular deaths or heart transplantation occurred. The 20\u2010year heart transplantation rate among CCSS osteosarcoma survivors (mean doxorubicin, 377\u00a0\u00b1\u00a0145\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) was 1.6% (vs 0% in P9754;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.13). Among randomized patients, serious cardiovascular outcomes (cardiomyopathy, ischemic heart disease, and stroke) ascertained by PHIS\/Medicaid occurred less commonly with dexrazoxane (5.6%) than without it (17.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02), although cardiomyopathy rates alone did not differ (4.4% vs 8.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.35).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dexrazoxane did not appear to adversely affect long\u2010term mortality, event\u2010free survival, or second cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.33974","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T05:36:04Z","timestamp":1634448964000},"page":"788-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Late health outcomes after dexrazoxane treatment: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-961X","authenticated-orcid":false,"given":"Eric J.","family":"Chow","sequence":"first","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aplenc","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda M.","family":"Vrooman","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston Children's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Doody","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Shung V.","family":"Huang","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-8603","authenticated-orcid":false,"given":"Saro H.","family":"Armenian","sequence":"additional","affiliation":[{"name":"City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Scott","family":"Baker","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-5683","authenticated-orcid":false,"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis S.","family":"Constine","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Freyer","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Kopp","sequence":"additional","affiliation":[{"name":"University of Arizona Tucson Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-0906","authenticated-orcid":false,"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle Children's Hospital Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Asselin","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-021X","authenticated-orcid":false,"given":"Cindy L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Children's Wisconsin Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Lipshultz","sequence":"additional","affiliation":[{"name":"Oishei Children's Hospital Roswell Park Comprehensive Center University at Buffalo Jacobs School of Medicine and Biomedical Sciences Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182a88099"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.3920"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00313"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.1373"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz108"},{"key":"e_1_2_8_7_1","first-page":"CD003917","article-title":"Cardioprotective interventions for cancer patients receiving anthracyclines","volume":"6","author":"Dalen EC","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"e_1_2_8_9_1","unstructured":"Orphan drug designations and approvals. US Food and Drug Administration. Accessed September 1 2021.https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/detailedIndex.cfm?cfgridkey=441314"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv357"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4473"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-292615"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184143"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24279"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25753"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027714"},{"key":"e_1_2_8_17_1","unstructured":"National Center for Health Statistics.National Death Index user's guide. Hyattsville MD 2013."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(86)90155-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143480"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30418-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118032985"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.457"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02856"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035153"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70204-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.8851"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.08.006"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016022"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.957480"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867305666220314194045"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.3879"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.11.003"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30072"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.33974","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.33974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:49:55Z","timestamp":1760280595000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.33974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2,15]]}},"alternative-id":["10.1002\/cncr.33974"],"URL":"https:\/\/doi.org\/10.1002\/cncr.33974","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}