{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:40:31Z","timestamp":1785253231768,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The significance of tumor\u2010infiltrating lymphocytes (TILs) in melanoma is debated. This article presents a multicenter, retrospective study assessing the predictive and prognostic value of TILs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with known TIL data. TILs were categorized as absent or present, which included nonbrisk (NB), brisk (B), and present but unspecified TIL levels. Clinicopathologic factors were correlated with TILs, sentinel lymph node (SLN) status, and melanoma\u2010specific survival (MSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 3203 patients were included. The median thickness was 1.5 mm, and 469 cases had SLN metastases. TILs were present in 2458 cases (76.7%), with NB, B, and unspecified TILs seen in 1691 (68.8%), 691 (28.1%), and 76 (3.1%), respectively. Multivariable analysis showed that the presence of TILs significantly predicted a negative SLN biopsy (<jats:italic>P<\/jats:italic> &lt; .05). The median follow\u2010up was 25.2 months. MSS was significantly better for cases with TILs than cases without TILs (<jats:italic>P<\/jats:italic> &lt; .001). According to multivariable analysis, age, gender, thickness, mitotic rate, ulceration, lymphovascular invasion, and SLN status were significantly prognostic of MSS (all <jats:italic>P<\/jats:italic> values &lt; .05). Although TILs were not prognostic of MSS, when multiple imputation was used and the SLN status was excluded, the presence of TILs was significantly prognostic of improved MSS (hazard ratio, 0.78; 95% confidence interval, 0.64\u20100.95; <jats:italic>P<\/jats:italic> = .0154).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TILs are a favorable marker because their presence significantly predicts a negative SLN, and the absence of TILs may be a prognostic marker of worse survival in patients with a positive SLN but not a negative SLN. TILs may also serve as a prognostic marker of survival when the SLN status is not considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34013","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T08:32:51Z","timestamp":1643704371000},"page":"1418-1428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is the presence of tumor\u2010infiltrating lymphocytes predictive of outcomes in patients with melanoma?"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-696X","authenticated-orcid":false,"given":"Steven L.","family":"Morrison","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Elenwa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Vetto","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley P.","family":"Leong","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center and Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-0011","authenticated-orcid":false,"given":"Mohammed","family":"Kashani\u2010Sabet","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center and Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Pockaj","sequence":"additional","affiliation":[{"name":"Mayo Clinic Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi E.","family":"Kosiorek","sequence":"additional","affiliation":[{"name":"Mayo Clinic Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Zager","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"},{"name":"Department of Oncologic Sciences University of South Florida Morsani College of Medicine Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-484X","authenticated-orcid":false,"given":"Vernon K.","family":"Sondak","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"},{"name":"Department of Oncologic Sciences University of South Florida Morsani College of Medicine Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L.","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mozzillo","sequence":"additional","affiliation":[{"name":"Istituto Tumori Napoli Fondazione G. 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