{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:39:29Z","timestamp":1760315969945,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013700","name":"National Comprehensive Cancer Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001320","name":"Roswell Park Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016056"],"award-info":[{"award-number":["P30CA016056"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ofatumumab is a humanized type 1 anti\u2010CD20 monoclonal antibody. Preclinical studies show improved complement\u2010mediated cytotoxicity (CMC) compared to rituximab in mantle cell lymphoma (MCL). This study evaluates the safety and efficacy of combining ofatumumab with HyperCVAD\/MA (O\u2010HyperCVAD) in newly diagnosed MCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010arm phase 2 study, 37 patients were treated with the combination of O\u2010HyperCVAD for 4 or 6 cycles, followed by high dose chemotherapy and autologous stem cell transplant. Primary objectives were overall response rate (ORR) and complete response (CR) rate at the end of therapy. Secondary objectives included minimal residual disease (MRD) negativity, progression\u2010free survival (PFS), and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 60 years; ORR was 86% and 73% achieved a CR by modified Cheson criteria. The MRD negativity rate was 78% after 2 cycles of therapy, increasing to 96% at the end of induction; median PFS and OS were 45.5 months and 56 months, respectively. Achieving a post\u2010induction CR by both imaging and flow cytometry was associated with improved PFS and OS. Early MRD negativity (post\u20102 cycles) was also associated with an improved PFS but not OS. There were 3 deaths while on therapy, and grades 3 and 4 adverse events (AEs) were observed in 22% and 68% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of ofatumumab to HyperCVAD\/HD\u2010MA led to high rates of MRD negativity by flow cytometry in patients with newly diagnosed MCL. Achieving a CR post\u2010induction by both imaging and flow cytometry is associated with improved overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34106","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T11:47:57Z","timestamp":1644839277000},"page":"1595-1604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ofatumumab plus HyperCVAD\/HD\u2010MA induction leads to high rates of minimal residual disease negativity in patients with newly diagnosed mantle cell lymphoma: Results of a phase 2 study"],"prefix":"10.1002","volume":"128","author":[{"given":"Pallawi","family":"Torka","sequence":"first","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-9670","authenticated-orcid":false,"given":"Othman S.","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishitha M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora E.","family":"Baysal","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kader","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"Groman","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Nichols","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory","family":"Mavis","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Tario","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AnneMarie W.","family":"Block","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila N. 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