{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:18:11Z","timestamp":1779927491958,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["29056"],"award-info":[{"award-number":["29056"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol consumption is a risk factor for a number of communicable and non\u2010communicable diseases, including several types of cancer. This article reports the burden of cancers attributable to alcohol consumption by age, sex, location, sociodemographic index (SDI), and cancer type from 1990 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Comparative Risk Assessment approach was used in the 2019 Global Burden of Disease study to report the burden of cancers attributable to alcohol consumption between 1990 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2019, there were globally an estimated 494.7 thousand cancer deaths (95% uncertainty interval [UI], 439.7 to 554.1) and 13.0 million cancer disability\u2010adjusted life\u2010years (DALYs; 95% UI, 11.6 to 14.5) that were attributable to alcohol consumption. The alcohol\u2010attributable DALYs were much higher in men (10.5 million; 95% UI, 9.2 to 11.8) than women (2.5 million; 95% UI, 2.2 to 2.9). The global age\u2010standardized death and DALY rates of cancers attributable to alcohol decreased by 14.7% (95% UI, 6.4% to 23%) and 18.1% (95% UI, 9.2% to 26.5%), respectively, over the study period. Central Europe had the highest age\u2010standardized death rates that were attributable to alcohol consumption(10.3; 95% UI, 8.7 to12.0). Moreover, there was an overall positive association between SDI and the regional age\u2010standardized DALY rate for alcohol\u2010attributable cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite decreases in age\u2010standardized deaths and DALYs, substantial numbers of cancer deaths and DALYs are still attributable to alcohol consumption. Because there is a higher burden in males, the elderly, and developed regions (based on SDI), these groups and regions should be prioritized in any prevention programs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34111","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T12:50:26Z","timestamp":1646311826000},"page":"1840-1852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Global, regional, and national cancer deaths and disability\u2010adjusted life\u2010years (DALYs) attributable to alcohol consumption in 204 countries and territories, 1990\u20102019"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-9072","authenticated-orcid":false,"given":"Saeid","family":"Safiri","sequence":"first","affiliation":[{"name":"Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-9720","authenticated-orcid":false,"given":"Seyed Aria","family":"Nejadghaderi","sequence":"additional","affiliation":[{"name":"Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Systematic Review and Meta\u2010Analysis Expert Group (SRMEG) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-1348","authenticated-orcid":false,"given":"Nahid","family":"Karamzad","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition and Food Sciences Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-9289","authenticated-orcid":false,"given":"Kristin","family":"Carson\u2010Chahhoud","sequence":"additional","affiliation":[{"name":"Australian Centre for Precision Health University of South Australia Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-868X","authenticated-orcid":false,"given":"Nicola Luigi","family":"Bragazzi","sequence":"additional","affiliation":[{"name":"Centre for Disease Modelling York University Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-6818","authenticated-orcid":false,"given":"Mark J. M.","family":"Sullman","sequence":"additional","affiliation":[{"name":"Department of Life and Health Sciences University of Nicosia Nicosia Cyprus"},{"name":"Department of Social Sciences University of Nicosia Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-561X","authenticated-orcid":false,"given":"Amir","family":"Almasi\u2010Hashiani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health Arak University of Medical Sciences Arak Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-2718","authenticated-orcid":false,"given":"Mohammad Ali","family":"Mansournia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2772-2316","authenticated-orcid":false,"given":"Gary S.","family":"Collins","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, NDORMS, Botnar Research Centre University of Oxford Oxford United Kingdom"},{"name":"NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-401X","authenticated-orcid":false,"given":"Jay S.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-3732","authenticated-orcid":false,"given":"Ali\u2010Asghar","family":"Kolahi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)31571\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2010.03164.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2010.02899.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.econedurev.2010.06.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010029184"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)31310\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109280"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1584"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010010\u20109548\u2010z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002585"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.094"},{"key":"e_1_2_9_13_1","volume-title":"Accelerating action to reduce the harmful use of alcohol","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00279\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30925\u20109"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)67725\u20102"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech\u20102020\u2010213820"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20106405.12159"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20102667(19)30231\u20102"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507017"},{"key":"e_1_2_9_22_1","volume-title":"Epidemiology of alcohol use in the WHO South\u2010East Asia Region"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010420"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2018.1517797"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078999"},{"key":"e_1_2_9_26_1","first-page":"20","article-title":"Alcohol use in the elderly: beyond the CAGE. Part 2: screening instruments and treatment strategies","volume":"61","author":"Culberson JW","year":"2006","journal-title":"Geriatrics"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2190\/pm.40.3.g"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2016.1151372"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.10.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14725"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090164"},{"key":"e_1_2_9_32_1","first-page":"240","article-title":"Development of new immunotherapy treatments in different cancer types","volume":"9","author":"Stanculeanu DL","year":"2016","journal-title":"J Med Life"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2013.04.002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1916623"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.7326\/m15\u20100754"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31954"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/326728"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4346576"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.11.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2009.02708.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2019.1705861"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687637.2018.1534944"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agaa025"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(18)30019\u20106"},{"key":"e_1_2_9_45_1","volume-title":"Planning and Developing Population\u2010Based Cancer Registration in Low\u2010 or Middle\u2010Income Settings","author":"Bray F","year":"2014"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010008\u20109288\u20105"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010019\u201001226\u20107"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010019\u201002958\u20101"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.34111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:10:53Z","timestamp":1760285453000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/cncr.34111"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34111","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]},"assertion":[{"value":"2021-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}