{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:11:58Z","timestamp":1785481918114,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["P50DE019032"],"award-info":[{"award-number":["P50DE019032"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R35DE026631"],"award-info":[{"award-number":["R35DE026631"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DC000027\u201029"],"award-info":[{"award-number":["5T32DC000027\u201029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Human papillomavirus (HPV) is responsible for a growing proportion of oropharyngeal squamous cell carcinomas (OPSCCs) among men and White individuals. Whether similar trends apply to women, non\u2010Whites, and non\u2010oropharyngeal squamous cell carcinomas (non\u2010OPSCCs) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This is a cross\u2010sectional analysis combining 2 multi\u2010institutional case series of incident head and neck squamous cell carcinoma (HNSCC) cases. Incident HNSCCs from 1995 to 2012 were enrolled retrospectively using banked tumor samples and medical record abstraction. Incident HNSCCs from 2013 to 2019 were enrolled prospectively. The prevalence of tumor HPV biomarkers was tested over 3 time periods (1995\u20102003, 2004\u20102012, and 2013\u20102019). Centralized testing was done for p16 immunohistochemistry (p16) and oncogenic HPV in situ hybridization (ISH).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 1209 incident cases of HNSCC were included. Prevalence of p16\u2010 and ISH\u2010positive tumors increased significantly for oropharynx cancers over time. The majority were positive after 2013 for White patients (p16, 92%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001; ISH 94%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), Black patients (p16, 72%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.021; ISH 67%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), and Hispanic patients (p16, 100%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04; ISH 100%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013). For women with OPSCC, the prevalence of p16\u2010 and ISH\u2010positive tumors increased significantly to 82% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and 78% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), respectively. For non\u2010OPSCCs, there was increased p16 and ISH positivity overall with 24% p16 and 16% ISH positivity in the most recent time period (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The majority of OPSCCs in US tertiary care centers are now p16 and ISH positive for all sex and race groups. In some populations in the United States, 91% of OPSCCs are now caused by HPV. Few non\u2010OPSCCs are p16 and ISH positive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34124","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T05:00:41Z","timestamp":1644296441000},"page":"1767-1774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prevalence of human papillomavirus in head and neck cancers at tertiary care centers in the United States over time"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7630-3863","authenticated-orcid":false,"given":"Nicholas","family":"Scott\u2010Wittenborn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gypsyamber","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery 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