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The current meta\u2010analysis was conducted to assess the safety of acupuncture in oncological patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched from their inception to August 7, 2020. Randomized controlled trials in oncological patients comparing invasive acupuncture with sham acupuncture, treatment as usual (TAU), or any other active control were eligible. Two reviewers independently extracted data on study characteristics and adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias Tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4590 screened articles, 65 were included in the analyses. The authors observed that acupuncture was not associated an with increased risk of intervention\u2010related AEs, nonserious AEs, serious AEs, or dropout because of AEs compared with sham acupuncture and an active control. Compared with TAU, acupuncture was not associated with an increased risk of intervention\u2010related AEs, serious AEs, or drop out because of AEs but was associated with an increased risk for nonserious AEs (odds ratio, 3.94; 95% confidence interval, 1.16\u201013.35; <jats:italic>P<\/jats:italic> = .03). However, the increased risk of nonserious AEs compared with TAU was not robust against selection bias. The meta\u2010analyses may have been biased because of the insufficient reporting of AEs in the original randomized controlled trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current review indicates that acupuncture is as safe as sham acupuncture and active controls in oncological patients. The authors recommend researchers heed the CONSORT (Consolidated Standards of Reporting Trials) safety and harm extension for reporting to capture the side effects and better investigate the risk profile of acupuncture in oncology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>According to this analysis, acupuncture is a safe therapy for the treatment of patients with cancer.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Acupuncture seems to be safe compared with sham acupuncture and active controls.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34165","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T09:23:48Z","timestamp":1646731428000},"page":"2159-2173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Safety of acupuncture in oncology: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"128","author":[{"given":"Melanie D.","family":"H\u00f6xtermann","sequence":"first","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Haller","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Aboudamaah","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Bachemir","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Dobos","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-8046","authenticated-orcid":false,"given":"Holger","family":"Cramer","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-0479","authenticated-orcid":false,"given":"Petra","family":"Voiss","sequence":"additional","affiliation":[{"name":"Evangelical Clinics Essen\u2010Mitte Department of Internal and Integrative Medicine Faculty of Medicine University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgm005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010007\u20100017\u2010y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26146"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2011.0456"},{"key":"e_1_2_8_8_1","volume-title":"WHO Global Report on Traditional and Complementary Medicine 2019 [License: CC BY\u2010NC\u2010SA 3.0 IGO]","author":"World Health Organization (WHO)","year":"2019"},{"key":"e_1_2_8_9_1","unstructured":"National Cancer Institute (NCI).NCI Dictionary of Cancer Terms: acupuncture. 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