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More recently, limited data have shown improved outcomes in select patients with 5\u2010year overall survival rates of approximately 60%. Despite these reported survival improvements, there is no significant improvement in disease\u2010free survival. Given the uncertain benefit with this therapeutic approach and a renewed investigational interest, we aimed to conduct a contemporary systematic review on LT for CRLM. A systematic review of the literature was performed according to the preferred reporting items for systematic reviews and meta\u2010analysis statement. English articles reporting on data regarding LT for CRLM were identified through the MEDLINE (via PubMed), Cochrane Library, and ClinicalTrials.gov databases (last search date: December 16th, 2021) by 2 researchers independently. A total of 58 studies (45 published and 13 ongoing) were included. Although early retrospective studies suggest the possibility that some carefully selected patients may benefit from LT, there is minimal prospective data on the topic and LT remains exploratory in the setting of CRLM. Additionally, several other challenges, such as the limited availability of deceased donor organs and defining appropriate selection criteria, remain when considering the implementation of LT for these patients. Further evidence from ongoing prospective trials is needed to determine if and to what extent there is a role for LT in patients with surgically unresectable CRLM.<\/jats:p>","DOI":"10.1002\/cncr.34170","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T11:19:14Z","timestamp":1647256754000},"page":"2243-2257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A contemporary systematic review on liver transplantation for unresectable liver metastases of colorectal cancer"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-271X","authenticated-orcid":false,"given":"Cody M.","family":"Lebeck Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-6909","authenticated-orcid":false,"given":"Ioannis A.","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepatobiliary Surgery and Liver Transplantation Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Vanderbilt University Medical Center\/Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophoclis P.","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepatobiliary Surgery and Liver Transplantation Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen K.","family":"Ciombor","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Vanderbilt University Medical Center\/Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepatobiliary Surgery and Liver Transplantation Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiologic Sciences Division of Interventional Radiology Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-0612","authenticated-orcid":false,"given":"Cathy","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Vanderbilt University Medical Center\/Vanderbilt\u2010Ingram Cancer Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American Cancer SocietyKey statistics for colorectal cancer. 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