{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:29Z","timestamp":1791388109752,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00205"],"award-info":[{"award-number":["PI18\/00205"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01472"],"award-info":[{"award-number":["PI18\/01472"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00231"],"award-info":[{"award-number":["PI21\/00231"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ruxolitinib is approved for patients with polycythemia vera (PV) who are resistant\/intolerant to hydroxyurea, but its impact on preventing thrombosis or disease\u2010progression is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, real\u2010world analysis was performed on the outcomes of 377 patients with resistance\/intolerance to hydroxyurea from the Spanish Registry of Polycythemia Vera according to subsequent treatment with ruxolitinib (n = 105) or the best available therapy (BAT; n = 272). Survival probabilities and rates of thrombosis, hemorrhage, acute myeloid leukemia, myelofibrosis, and second primary cancers were calculated according to treatment. To minimize biases in treatment allocation, all results were adjusted by a propensity score for receiving ruxolitinib or BAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients receiving ruxolitinib had a significantly lower rate of arterial thrombosis than those on BAT (0.4% vs 2.3% per year; <jats:italic>P<\/jats:italic> = .03), and this persisted as a trend after adjustment for the propensity to have received the drug (incidence rate ratio, 0.18; 95% confidence interval, 0.02\u20101.3; <jats:italic>P<\/jats:italic> = .09). There were no significant differences in the rates of venous thrombosis (0.8% and 1.1% for ruxolitinib and BAT, respectively; <jats:italic>P<\/jats:italic> = .7) and major bleeding (0.8% and 0.9%, respectively; <jats:italic>P<\/jats:italic> = .9). Ruxolitinib exposure was not associated with a higher rate of second primary cancers, including all types of neoplasia, noncutaneous cancers, and nonmelanoma skin cancers. After a median follow\u2010up of 3.5 years, there were no differences in survival or progression to acute leukemia or myelofibrosis between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that ruxolitinib treatment for PV patients with resistance\/intolerance to hydroxyurea may reduce the incidence of arterial thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Ruxolitinib is better than other available therapies in achieving hematocrit control and symptom relief in patients with polycythemia vera who are resistant\/intolerant to hydroxyurea, but we still do not know whether ruxolitinib provides an additional benefit in preventing thrombosis or disease progression.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We retrospectively studied the outcomes of 377 patients with resistance\/intolerance to hydroxyurea from the Spanish Registry of Polycythemia Vera according to whether they subsequently received ruxolitinib (n = 105) or the best available therapy (n = 272).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our findings suggest that ruxolitinib could reduce the incidence of arterial thrombosis, but a disease\u2010modifying effect could not be demonstrated for ruxolitinib in this patient population.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34195","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:09:24Z","timestamp":1649851764000},"page":"2441-2448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Real\u2010world analysis of main clinical outcomes in patients with polycythemia vera treated with ruxolitinib or best available therapy after developing resistance\/intolerance to hydroxyurea"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-4619","authenticated-orcid":false,"given":"Alberto","family":"Alvarez\u2010Larr\u00e1n","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garrote","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Ferrer\u2010Mar\u00edn","sequence":"additional","affiliation":[{"name":"Hospital Morales Messeguer, Universidad Cat\u00f3lica San Antonio de Murcia, Murcia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"P\u00e9rez\u2010Encinas","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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