{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:49:48Z","timestamp":1792507788445,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["MRSG\u201018\u2010020\u201001\u2010 CPPB"],"award-info":[{"award-number":["MRSG\u201018\u2010020\u201001\u2010 CPPB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR003097"],"award-info":[{"award-number":["KL2TR003097"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with lymphoma have an increased risk of venous thromboembolism (VTE). The authors examined the risk of VTE and subsequent health care utilization in elderly patients with diffuse large B cell lymphoma (DLBCL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 5537 DLBCL patients \u226566 years old enrolled in Medicare from the Surveillance, Epidemiology, and End Results registry and a noncancer control group of Medicare beneficiaries (n = 5537) were identified. Cumulative incidence function to examine the risk of VTE 12 months after DLBCL diagnosis was used. Fine and Gray method was used to examine the risk factors associated with VTE risk in multivariable models. Total number of hospitalizations, outpatient visits, and Medicare spending were compared in DLBCL patients with and without VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VTE was diagnosed in 8.3% DLBCL patients and 1.5% controls, yielding an 8.6\u2010fold higher risk of VTE in DLBCL in adjusted analysis (95% confidence interval [CI], 6.62\u201011.20;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Multivariable regression analysis showed that precancer VTE history was associated with an increased risk of developing VTE after a DLBCL diagnosis (hazard ratio [HR], 5.39; 95% CI, 4.39\u20106.63), and Asian individuals were associated with a lower risk (HR, 0.54; 95% CI, 0.29\u20101.00). Patients newly diagnosed with VTE after lymphoma had a 1.7\u2010fold higher rate of hospitalization and a 1.2\u2010fold higher rate of outpatient visits compared to those without, resulting in excess Medicare spending of $22,208 in the first year after DLBCL diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elderly patients with DLBCL have an elevated risk of VTE resulting in excess health care utilization. VTE history before DLBCL was associated with increased risk of post\u2010DLBCL VTE, and Asian individuals were associated with a lower risk of VTE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.34210","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T11:49:21Z","timestamp":1648813761000},"page":"2348-2357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Venous\u2010thromboembolism and associated health care utilization in elderly patients with diffuse large B cell lymphoma"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-4754","authenticated-orcid":false,"given":"Radhika","family":"Gangaraju","sequence":"first","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-2083","authenticated-orcid":false,"given":"Elizabeth S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-5683","authenticated-orcid":false,"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-8446","authenticated-orcid":false,"given":"Kelly M.","family":"Kenzik","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01804.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02374.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.15.1653"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2019.1703190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S39964"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602504"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1185782"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11623"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.05.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.09.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1995.tb00214.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.08.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.03.019"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600560991"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-017-1065-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.6.585"},{"key":"e_1_2_8_19_1","first-page":"3","article-title":"Updated overview of the SEER\u2010Medicare data: enhanced content and applications","volume":"2020","author":"Enewold L","year":"2020","journal-title":"JNCI Monographs"},{"issue":"8","key":"e_1_2_8_20_1","first-page":"IV\u20103\u201018","article-title":"Overview of the SEER\u2010Medicare data: content, research applications, and generalizability to the United States elderly population","volume":"40","author":"Warren JL","year":"2002","journal-title":"Med Care"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.7273"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.03.009"},{"key":"e_1_2_8_23_1","unstructured":"Cancer Research Network.Cancer Therapy Look\u2010Up Tables. 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