{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:35:43Z","timestamp":1784979343612,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The presence of peripheral blasts (PB) is a negative prognostic factor in patients with primary and secondary myelofibrosis (MF) and PB \u22654% was associated with a particularly unfavorable prognosis. Ruxolitinib (RUX) is the JAK1\/2 inhibitor most used for treatment of MF\u2010related splenomegaly and symptoms. Its role has not been assessed in correlation with PB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 794 chronic\u2010phase MF patients treated with RUX, we evaluated the impact of baseline percentage of PB on response (spleen and symptoms responses) and outcome (RUX discontinuation\u2010free, leukemia\u2010free, and overall survival). Three subgroups were compared: PB\u20100 (no PB, 61.3%), PB\u20104 (PB 1%\u20104%, 33.5%), and PB\u20109 (PB 5%\u20109%, 5.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 and 6 months, spleen responses were less frequently achieved by PB\u20104 (<jats:italic>P<\/jats:italic> = .001) and PB\u20109 (<jats:italic>P<\/jats:italic> = .004) compared to PB\u20100 patients. RUX discontinuation\u2010free, leukemia\u2010free, and overall survival were also worse for PB\u20104 and PB\u20109 patients (<jats:italic>P<\/jats:italic> = .001, <jats:italic>P<\/jats:italic> = .002, and <jats:italic>P<\/jats:italic> &lt; .001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Personalized approaches beyond RUX monotherapy may be useful in PB\u20104 and particularly in PB\u20109 patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34216","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T13:18:29Z","timestamp":1648819109000},"page":"2449-2454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Peripheral blasts are associated with responses to ruxolitinib and outcomes in patients with chronic\u2010phase myelofibrosis"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-5668","authenticated-orcid":false,"given":"Francesca","family":"Palandri","sequence":"first","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-2896","authenticated-orcid":false,"given":"Daniela","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d Bologna Italy"},{"name":"Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0812","authenticated-orcid":false,"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-6491","authenticated-orcid":false,"given":"Elisabetta","family":"Abruzzese","sequence":"additional","affiliation":[{"name":"Ospedale S. Eugenio Universit\u00e0 Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Caocci","sequence":"additional","affiliation":[{"name":"Polo oncologico \u201cA. Businco\u201d Universit\u00e0 degli studi di Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Elli","sequence":"additional","affiliation":[{"name":"Ospedale San Gerardo Azienda Socio Sanitaria Territoriale Monza Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-6772","authenticated-orcid":false,"given":"Giuseppe","family":"Auteri","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d Bologna Italy"},{"name":"Dipartimento di Medicina Specialistica Diagnostica e Sperimentale Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-2621","authenticated-orcid":false,"given":"Mario","family":"Tiribelli","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Integrata di Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-9697","authenticated-orcid":false,"given":"Nicola","family":"Polverelli","sequence":"additional","affiliation":[{"name":"Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Miglino","sequence":"additional","affiliation":[{"name":"IRCCS Policlinico San Martino Genova Italy"},{"name":"Dipartimento di Medicina interna e Specialit\u00e0 mediche Universit\u00e0 di Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian H.","family":"Heidel","sequence":"additional","affiliation":[{"name":"Innere Medicine C Universit\u00e4tsmedizin Greifswald Greifswald Germany"},{"name":"Leibniz Institute on Aging Fritz Lipmann\u2010Institute Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Tieghi","sequence":"additional","affiliation":[{"name":"Azienda USL \u2010 IRCCS di Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-9654","authenticated-orcid":false,"given":"Giulia","family":"Benevolo","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Citt\u00e0 della Salute e della Scienza Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloise","family":"Beggiato","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia Universit\u00e0 di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fava","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Ordine Mauriziano di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cavazzini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Arcispedale S. 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