{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:41:27Z","timestamp":1788514887726,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA185811"],"award-info":[{"award-number":["R21 CA185811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 CA159357"],"award-info":[{"award-number":["R03 CA159357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Breast cancer survival is increasing, making late effects such as cardiovascular disease (CVD) more relevant. The purpose of this study was to evaluate incident CVD following breast cancer diagnosis among long\u2010term survivors and to investigate possible risk factors for CVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort of 6641 breast cancer survivors diagnosed between 1997 and 2009 who survived at least 10\u00a0years was identified within the Utah Cancer Registry. In addition, 36,612 cancer\u2010free women from the general population, matched by birth year and state, were identified within the Utah Population Database. Cox proportional hazards models were used to calculate CVD hazard ratios (HRs) for &gt;10 to 15 and &gt;15\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Long\u2010term breast cancer survivors had an increased risk of newly diagnosed diseases of the circulatory system (HR, 1.32; 99% confidence interval [CI], 1.00\u20101.75) from 10 to 15\u00a0years following cancer diagnosis compared with the general population. No increased CVD risks were observed after 15\u00a0years. Breast cancer survivors with Charlson Comorbidity Index score \u22652 had a significantly higher risk of diseases of the circulatory system (HR, 2.64; 95% CI, 1.08\u20106.45) beyond 10\u00a0years following breast cancer diagnosis. Similarly, older age, obesity, lower education, and family history of CVD and breast cancer were risk factors for heart and circulatory system diseases among long\u2010term breast cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Risk of CVD compared to the general population was moderate among this cohort of long\u2010term breast cancer survivors between 10 to 15\u00a0years since cancer diagnosis. Awareness of CVD risks is important for breast cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34224","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T16:22:55Z","timestamp":1652458975000},"page":"2826-2835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cardiovascular disease risk in long\u2010term breast cancer survivors: A population\u2010based cohort study"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-0317","authenticated-orcid":false,"given":"Alzina","family":"Koric","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Public Health Department of Family and Preventive Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Pin","family":"Chang","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Public Health Department of Family and Preventive Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayarmaa","family":"Mark","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"Division of Public Health Department of Family and Preventive Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Rowe","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Snyder","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dodson","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant G.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"University of Utah Health Sciences Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute Salt Lake City Utah"},{"name":"University of Utah Health Sciences Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource Population Sciences, Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource Population Sciences, Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-9436","authenticated-orcid":false,"given":"Ankita P.","family":"Date","sequence":"additional","affiliation":[{"name":"Pedigree and Population Resource Population Sciences, Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa H.","family":"Gren","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family and Preventive Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Porucznik","sequence":"additional","affiliation":[{"name":"Division of Public Health Department of Family and Preventive Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Haaland","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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