{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:41:39Z","timestamp":1790948499348,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007903","name":"Bloodwise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The presence of <jats:italic>TP53<\/jats:italic> mutations is associated with an unfavorable outcome in patients allografted for acute myeloid leukemia (AML), leading some to question the benefit of an allogeneic stem cell transplantation (allo\u2010SCT) for this patient group, although this has not been studied in a large cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 780 patients with AML in first complete remission, with either intermediate\u2010 or adverse\u2010risk cytogenetics, whose <jats:italic>TP53<\/jats:italic> mutation status was reported, were included in this study from the European Society for Blood and Marrow Transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Two\u2010year overall survival (OS) was impaired in patients (n\u00a0=\u00a0179) with evidence of a <jats:italic>TP53<\/jats:italic> mutation at diagnosis (35.1%; 95% confidence interval [CI], 26.7\u201343.7) as compared to the cohort without (n\u00a0=\u00a0601) (64%; 95% CI, 59.1\u201368.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). In patients with mutant <jats:italic>TP53<\/jats:italic> AML with no evidence of either chromosome 17p loss (17p\u2013) and\/or complex karyotype (CK) (n\u00a0=\u00a053, 29.6%), 2\u2010year OS was 65.2% (95% CI, 48.4\u201377.6). This was not significantly different to patients without <jats:italic>TP53<\/jats:italic> mutations. In patients with mutant <jats:italic>TP53<\/jats:italic> AML with either 17p\u2013 and\/or CK (n\u00a0=\u00a0126, 70.4%), the OS was lower (24.6%; 95% CI, 16.2\u201334; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In summary, the adverse prognostic effect of <jats:italic>TP53<\/jats:italic> mutations in AML following an allo\u2010SCT is not evident in patients with neither co\u2010occurring 17p\u2013 and\/or CK, and these data inform decisions regarding allo\u2010SCT in patients with <jats:italic>TP53<\/jats:italic> mutant AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34268","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T11:10:15Z","timestamp":1653477015000},"page":"2922-2931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Additional cytogenetic features determine outcome in patients allografted for <i>TP53<\/i> mutant acute myeloid leukemia"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-069X","authenticated-orcid":false,"given":"Justin","family":"Loke","sequence":"first","affiliation":[{"name":"Cancer Research UK, Clinical Trials Unit University of Birmingham  Birmingham UK"},{"name":"Birmingham Center for Cellular Therapy and Transplantation Centre for Clinical Haematology, Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party, Paris Study Office European Society for Blood and Marrow Transplantation  Paris France"},{"name":"Haematology Department AP\u2010HP, Saint Antoine Hospital  Paris France"},{"name":"INSERM, Centre de Recherche Saint\u2010Antoine (CRSA) Sorbonne Universit\u00e9s, UPMC Univ Paris 06  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Craddock","sequence":"additional","affiliation":[{"name":"Cancer Research UK, Clinical Trials Unit University of Birmingham  Birmingham UK"},{"name":"Birmingham Center for Cellular Therapy and Transplantation Centre for Clinical Haematology, Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Labussi\u00e8re\u2010Wallet","sequence":"additional","affiliation":[{"name":"Hopital\u2010Lyon Sud, Hospices Civils de Lyon, Pierre B\u00e9nite  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Transplantation Centre  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Hendrik","family":"Veelken","sequence":"additional","affiliation":[{"name":"Leiden University Hospital BMT Centre Leiden  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hospital Clinic, Department of Hematology IDIBAPS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lise","family":"Menard","sequence":"additional","affiliation":[{"name":"Centre Henri Becquerel, Hematology  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Bug","sequence":"additional","affiliation":[{"name":"Department of Medicine Goethe University Frankfurt  Frankfurt Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Program, Department of Internal Medicine American University of Beirut Medical Center  Beirut Lebanon"},{"name":"Department of Anatomy, Cell Biology and Physiological Sciences American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-4401","authenticated-orcid":false,"given":"Sebastian","family":"Giebel","sequence":"additional","affiliation":[{"name":"Maria Sklodowsk\u2010Curie Memorial Cancer Centre and Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eolia","family":"Brissot","sequence":"additional","affiliation":[{"name":"Haematology Department AP\u2010HP, Saint Antoine Hospital  Paris France"},{"name":"INSERM, Centre de Recherche Saint\u2010Antoine (CRSA) Sorbonne 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