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Depression is more prevalent in breast cancer survivors and is thought to be a vulnerability factor for biological aging. A lifetime history of depression and cumulative lifetime number of depression episodes could hypothetically be associated with an accelerated rate of biological aging as indexed by attrition of telomere length in a prospective cohort of breast cancer survivors who were not currently depressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breast cancer survivors (<jats:italic>n<\/jats:italic>\u00a0=\u00a0206) without current depression were recruited from a large community\u2010based health plan and were assessed for depression history by a structured diagnostic interview. Blood specimens were provided at baseline and every 8\u2009months over 24\u2009months to measure peripheral blood mononuclear cell (PBMC) telomere length. Mixed linear models examined associations of depression history and number of depression episodes with change in telomere length, adjusting for demographic, comorbidity, and cancer\u2010specific factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the fully adjusted model, depression history predicted attrition of PBMC telomere length over 24\u2009months (Beta [SE]\u00a0=\u00a0\u2212.006 [.002], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Greater number of depressive episodes over the lifetime was also associated with accelerated attrition of PBMC telomere length over 24\u2009months (Beta [SE]\u00a0=\u00a0\u2212.004 [.001], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In breast cancer survivors without current depression, telomere attrition over 24\u2009months was greatest in those with a lifetime depression history, particularly those with the greatest number of episodes of major depressive disorder over their lifetime. Depression history and its cumulative burden may contribute to accelerated biological aging, with implications for risk of morbidity and mortality in breast cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34329","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T03:01:20Z","timestamp":1654570880000},"page":"3109-3119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Accelerated mononuclear cell telomere attrition in breast cancer survivors with depression history: A 2\u2010year longitudinal cohort study"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-0819","authenticated-orcid":false,"given":"Judith E.","family":"Carroll","sequence":"first","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology UCLA Jane &amp; Terry Semel Institute for Neuroscience &amp; Human Behavior and Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Olmstead","sequence":"additional","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology UCLA Jane &amp; Terry Semel Institute for Neuroscience &amp; Human Behavior and Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-3330","authenticated-orcid":false,"given":"Reina","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology UCLA Jane &amp; Terry Semel Institute for Neuroscience &amp; Human Behavior and Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles  Los Angeles California 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