{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:06:40Z","timestamp":1783732000935,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009634","name":"Susan G. Komen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Weight gain after a breast cancer diagnosis is common and is associated with inferior outcomes. Young survivors may be especially susceptible to weight changes given the impact of treatment on menopausal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors identified women who were diagnosed with stage 0 to III breast cancer at age 40\u2009years or younger between 2006 and 2016 from a multicenter prospective cohort. Self\u2010reported weight was collected at diagnosis and at 1\u2009year and 3\u2009years postdiagnosis. Tumor and treatment data were obtained from medical records and patient surveys. Multinomial logistic regression was used to identify the factors associated with weight gain (\u22655%) or weight loss (\u22655%) versus stable weight at 1\u2009year and 3\u2009years postdiagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 956 women with a median age of 37\u2009years at diagnosis. Mean weight significantly increased over time from 66.54\u2009\u00b1\u200914.85\u2009kg at baseline to 67.33\u2009\u00b1\u200915.53 and 67.77\u2009\u00b1\u200914.65\u2009kg at 1\u2009year and 3\u2009years, respectively (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.001 for both comparisons). The proportion of women experiencing \u22655% weight gain increased from 24.8% at 1\u2009year to 33.9% at 3\u2009years. At 1\u2009year, less self\u2010perceived financial comfort, Black race, and stage III disease were significantly associated with weight gain; at 3\u2009years, only less self\u2010perceived financial comfort remained significant. Baseline overweight or obesity was significantly associated with weight loss at both time points. Chemotherapy, endocrine therapy, and treatment\u2010related menopause were not associated with weight change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One third of young breast cancer survivors experienced clinically significant weight gain 3\u2009years after diagnosis; however, treatment\u2010related associations were not observed. Age\u2010appropriate lifestyle interventions, including the reduction of financial barriers, are needed to prevent weight gain in this high\u2010risk population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34342","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T09:03:35Z","timestamp":1656666215000},"page":"3158-3169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Body weight changes and associated predictors in a prospective cohort of young breast cancer survivors"],"prefix":"10.1002","volume":"128","author":[{"given":"Tal","family":"Sella","sequence":"first","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenying","family":"Tan\u2010Wasielewski","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-6385","authenticated-orcid":false,"given":"Shoshana M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Poorvu","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabihah","family":"Tayob","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-332X","authenticated-orcid":false,"given":"Kathryn J.","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Department of Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari I.","family":"Gelber","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-6543","authenticated-orcid":false,"given":"Lidia","family":"Schapira","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Come","sequence":"additional","affiliation":[{"name":"Breast Cancer Program, Beth Israel Deaconess Medical Center and Dana\u2010Farber\/Harvard Cancer Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Peppercorn","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia F.","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University of Colorado Cancer Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-4824","authenticated-orcid":false,"given":"Ann H.","family":"Partridge","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Ligibel","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614362"},{"key":"e_1_2_10_3_1","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health. 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