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The goal of this work was to assess the prevalence of white adipose tissue (WAT) inflammation in patients with endometrial cancer (EC), and the association with circulating inflammation markers. Furthermore, the aim was to characterize the pathways activated in and the cell type composition of adipose tissue in patients with EC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adipose tissue and blood samples were prospectively collected from 101 patients with EC at initial surgery. WAT inflammation was determined based on adipocytes surrounded by macrophages forming crown\u2010like structures. Circulating levels of metabolic syndrome\u2013associated and inflammatory markers were quantified. RNA\u2010sequencing was performed on adipose samples (<jats:italic>n<\/jats:italic>\u00a0=\u200955); differential gene expression, pathway, and cellular decomposition analyses were performed using state\u2010of\u2010the\u2010art bioinformatics methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WAT inflammation was identified in 46 (45.5%) of 101 EC patients. Dyslipidemia, hypertension, and diabetes mellitus were significantly associated with WAT inflammation (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). WAT inflammation was associated with greater body mass index (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and higher circulating levels of leptin, high\u2010sensitivity C\u2010reactive protein, and interleukin\u20106, as well as lower levels of adiponectin and sex hormone\u2013binding globulin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). Transcriptomic analysis demonstrated increased levels of proinflammatory and pro\u2010neoplastic\u2013related gene expression in inflamed omental adipose tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WAT inflammation is associated with metabolic syndrome, obesity, and inflammatory markers, as well as increased expression of proinflammatory and proneoplastic genes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34356","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T16:53:38Z","timestamp":1657126418000},"page":"3297-3309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer"],"prefix":"10.1002","volume":"128","author":[{"given":"Lea A.","family":"Moukarzel","sequence":"first","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Internal Medicine University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthe","family":"Stylianou","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lobaugh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Wu","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Pedra","family":"Nobre","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Iasonos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Zoppoli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip D.","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem R.","family":"Abu\u2010Rustum","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Obstetrics\/Gynecology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance A.","family":"Broach","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Obstetrics\/Gynecology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-5235","authenticated-orcid":false,"given":"Neil M.","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Breast Medicine Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-1270","authenticated-orcid":false,"given":"Britta","family":"Weigelt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-7614","authenticated-orcid":false,"given":"Vicky","family":"Makker","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill 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