{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:11:34Z","timestamp":1788286294487,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013227","name":"Health Promotion Administration, Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["A1091115"],"award-info":[{"award-number":["A1091115"]}],"id":[{"id":"10.13039\/100013227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of different soft tissue sarcoma (STS) histotypes among ethnic and geographic populations has not been comprehensively investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2013 to 2016 were obtained from national cancer registry databases in France and Taiwan. Liposarcoma (LPS), leiomyosarcoma (LMS), angiosarcoma (AS), synovial sarcoma (SS), and malignant peripheral nerve sheath tumor (MPNST) were selected as index STSs to estimate the age\u2010standardized incidence rates (ASRs) and other clinical features between patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 9398 patients (7148 from France and 2250 from Taiwan) were included. The ASRs of AS (5.4 vs. 2.8) and MPNST (2.0 vs. 1.0) were significantly higher in Taiwan; France had significantly higher ASRs for LPS (12.0 vs. 10.0), LMS (9.7 vs. 7.6), and SS (1.7 vs. 1.2). Patients in Taiwan with LMS or LPS were younger than their French counterparts. With regard to the distribution according to primary anatomic site, French patients had higher odds for extremity and truncal LMS (odds ratio [OR], 2.84; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), AS (OR, 2.67; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), MPNST (OR, 1.55; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027), and LPS (OR, 1.38; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and for breast AS (OR, 10.58; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Taiwanese patients had higher odds for liver AS (OR, 10.72; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and uterine LMS (OR, 3.21; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). SS age and distribution according to primary anatomic site did not differ significantly between the French and Taiwanese populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant differences in the incidence and clinical characteristics of index STS suggested that geographic (environmental) and ethnicity factors likely play a vital role in the pathogenesis of STS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34372","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:21:12Z","timestamp":1657182072000},"page":"3360-3369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Soft tissue sarcoma incidences and clinical characteristics are significantly different in France and Taiwan"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-4029","authenticated-orcid":false,"given":"Tom Wei\u2010Wu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruru Chun\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"},{"name":"Taiwan Cancer Registry  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Le Cesne","sequence":"additional","affiliation":[{"name":"Medical Oncology Gustave Roussy Institute\u2013Cancer Campus  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Italiano","sequence":"additional","affiliation":[{"name":"Early Phase Trials Unit Bergonie Institute  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"},{"name":"Taiwan Cancer Registry  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Penel","sequence":"additional","affiliation":[{"name":"General Oncology Department, Oscar Lambret Center  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-7672","authenticated-orcid":false,"given":"Wen\u2010Chung","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University  Taipei Taiwan"},{"name":"Taiwan Cancer Registry  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bompas","sequence":"additional","affiliation":[{"name":"Western Oncology Institute  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Valentin","sequence":"additional","affiliation":[{"name":"Claudius Regaud Institute  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Anract","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Assistance publique Hopitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Firmin","sequence":"additional","affiliation":[{"name":"Montpellier Cancer Institute  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Duffaud","sequence":"additional","affiliation":[{"name":"Medical Oncology Greater Paris University Hospitals  Marseilles France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Lii","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Ducimetiere","sequence":"additional","affiliation":[{"name":"Medicine Department, Leon Berard Center  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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