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This study aimed to evaluate the association between SVR and outcomes in patients with active HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors performed a multicenter, retrospective cohort study including consecutive adults with HCV cirrhosis and treatment\u2010naive HCC diagnosed between 2014 and 2018. Patients were stratified into two groups: active viremia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0431) and SVR before HCC diagnosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0135). All patients underwent nonsurgical therapy as their initial treatment and were followed until liver transplantation, last follow\u2010up, or death. The primary outcome was incident or worsening hepatic decompensation within 6\u2009months and the secondary outcome was overall survival. All analyses used inverse probability of treatment weights (IPTW) to account for differences between the nonrandomized cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010SVR patients had significantly lower odds of hepatic decompensation compared to viremic patients (odds ratio [OR], 0.18; 95% confidence interval [CI], 0.06\u20130.59). Results were consistent among subgroups of patients with Child Pugh A cirrhosis (OR, 0.22; 95% CI, 0.04\u20130.77), Barcelona Clinic Liver Cancer stage B\/C HCC (OR, 0.20; 95% CI, 0.04\u20130.65), and those receiving nonablative HCC therapies (OR, 0.21; 95% CI, 0.07\u20130.67). However, in IPTW multivariable Cox regression, SVR was not associated with improved survival (hazard ratio, 0.79; 95% CI, 0.56\u20131.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with HCV\u2010related HCC and SVR are less likely to experience hepatic decompensation than viremic patients, suggesting patients with HCC who are undergoing nonsurgical therapies may benefit from DAA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34378","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:46:44Z","timestamp":1657183604000},"page":"3470-3478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between sustained virological response and clinical outcomes in patients with hepatitis C infection and hepatocellular carcinoma"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-9933","authenticated-orcid":false,"given":"Neehar D.","family":"Parikh","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarouf A.","family":"Hoteit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7834-9825","authenticated-orcid":false,"given":"Ju Dong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division 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