{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:50:42Z","timestamp":1778802642512,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["1UL1TR003167"],"award-info":[{"award-number":["1UL1TR003167"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have assessed interventions aimed at managing nonmedical opioid use (NMOU) behavior among patients with cancer. The authors developed the Compassionate High\u2010Alert Team (CHAT) intervention to manage patients receiving opioids for cancer pain who demonstrate NMOU behavior. The objective of this study was to determine the change in frequency of NMOU behaviors, pain intensity, and opioid requirements among those who received the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 patients receiving opioids for cancer pain that had documented evidence of NMOU and received the CHAT intervention were reviewed. Demographic and clinical information such as NMOU behaviors, pain scores, and morphine equivalent daily dose at baseline, 3, and 6\u2009months post\u2010intervention was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NMOU behaviors significantly decreased from a median (interquartile range) of 2 (1\u20133) at baseline to 0 (0\u20131) at both 3 and 6\u2009months post\u2010intervention (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). A total of 45 of 75 (60%) and 31 of 50 (62%) of CHAT recipients achieved complete response to the intervention at 3 and 6\u2009months, respectively. Higher baseline number of NMOU behaviors was independently associated with patient response to the intervention (odds ratio [OR], 1.97; 95% confidence interval [CI],1.09\u20134.28, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.049 at 3\u2009months; OR, 2.5; 95% CI, 1.20\u20136.47, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03 at 6\u2009months). The median pain score decreased from 7 at baseline to 6 at both 3 and 6\u2009months (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Morphine equivalent daily dose did not significantly change during that same period (143\u2009mg\/day vs. 139\u2009mg\/day, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most patients who received the CHAT intervention improved in their NMOU behaviors and pain intensity scores 3 and 6\u2009months post\u2010intervention. These preliminary findings support the efficacy of CHAT in managing patients receiving opioids for cancer pain who demonstrate NMOU behavior.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34392","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:00:40Z","timestamp":1661241640000},"page":"3718-3726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interdisciplinary intervention for the management of nonmedical opioid use among patients with cancer pain"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-6108","authenticated-orcid":false,"given":"Joseph A.","family":"Arthur","sequence":"first","affiliation":[{"name":"Department of Palliative, Rehabilitation, and Integrative Medicine The University of Texas MD Anderson Cancer Center  Houston Texas 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Amaram\u2010Davila","sequence":"additional","affiliation":[{"name":"Department of Palliative, Rehabilitation, and Integrative Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7628-8675","authenticated-orcid":false,"given":"Akhila","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Palliative, Rehabilitation, and Integrative Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-6607","authenticated-orcid":false,"given":"David","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Palliative, Rehabilitation, and Integrative Medicine The University of Texas MD Anderson Cancer Center  Houston Texas 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