{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:57:32Z","timestamp":1789441052944,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171181"],"award-info":[{"award-number":["BK20171181"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>CD5\u2010positive diffuse large B\u2010cell lymphoma (DLBCL) is a clinically rare subtype of DLBCL with aggressive clinical manifestations and a poor prognosis. It has been demonstrated that the prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is a significant prognostic factor for several types of lymphoma. The objective of this multicenter retrospective study was to explore the prognostic value of the PNI in patients with CD5\u2010positive DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 207 patients with CD5\u2010positive DLBCL were recruited from 11 centers of the Huaihai Lymphoma Working Group. Maximally selected rank statistics analysis was used to identify optimal cutoff points for the PNI. A Cox proportional hazards model was used for univariable and multivariable analyses. Kaplan\u2013Meier curves were used to calculate survival rates and draw survival curves, and the log\u2010rank test was used to compare differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at diagnosis was 61\u2009years, and the 5\u2010year overall survival rate was 47.5%. According to the maximally selected rank statistics analysis, a score of 49.7 was the optimal cutoff point for the PNI. Subgroup analysis showed that the PNI could re\u2010stratify patients in BCL\u20102\u2013negative, MYC\u2010negative, high\u2010intermediate\u2013risk and high\u2010risk International Prognostic Index, BCL\u20106\u2013positive and BCL\u20106\u2013negative, high Ki\u201067 score (\u22650.9), Ann Arbor stage III\/IV, Eastern Cooperative Oncology Group performance status \u22652, and germinal center B subgroups. Multivariable analysis revealed that PNI, age, Eastern Cooperative Oncology Group performance status, albumin level, and red blood cell count were independent prognostic factors for CD5\u2010positive DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PNI was a significant prognostic indicator for CD5\u2010positive DLBCL and was able to re\u2010stratify the prognosis for clinicopathologic subgroups of patients with CD5\u2010positive DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34405","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T10:54:41Z","timestamp":1659783281000},"page":"3487-3494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Value of the prognostic nutritional index (<scp>PNI<\/scp>) in patients with newly diagnosed, <scp>CD5<\/scp>\u2010positive diffuse large B\u2010cell lymphoma: A multicenter retrospective study of the Huaihai Lymphoma Working Group"],"prefix":"10.1002","volume":"128","author":[{"given":"Sha","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingpei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianci","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Personnel, Suqian First Hospital  Suqian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingzong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiying","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First People's Hospital of Changzhou  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Huai'an First People's Hospital, Huai'an Jiangsu  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taigang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The General Hospital of Wanbei Coal\u2010Electric Group  Suzhou Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Yancheng First People's Hospital  Yancheng Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Taian Central Hospital, Taian  Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Xuzhou Medical University  Xuzhou Jiangsu China"},{"name":"Center for Medical Statistics and Data Analysis, School of Public Health Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-7074","authenticated-orcid":false,"given":"Wei","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Huaihai Lymphoma Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.09.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq627"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.754180"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1614289"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24299"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12847"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-524108"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90246-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00877"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.55936"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2019-0303"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000493"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3540-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1540718"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2052-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S340822"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq057"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2657"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.05.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12810"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3479"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3754"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497454"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.656741"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025127"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.867065"},{"key":"e_1_2_8_28_1","first-page":"3017","article-title":"Prognostic performance of lymphocyte\u2010to\u2010monocyte ratio in diffuse large B\u2010cell lymphoma: an updated meta\u2010analysis of eleven reports","volume":"9","author":"Sun HL","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01535-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1077-7"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.34405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:44:27Z","timestamp":1760262267000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,6]]},"references-count":29,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cncr.34405"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34405","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,6]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}