{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:48:09Z","timestamp":1782427689769,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07CA211107"],"award-info":[{"award-number":["K07CA211107"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients taking adjuvant endocrine therapy (AET) after breast cancer face adherence challenges and symptom\u2010related distress. We conducted a randomized trial to evaluate the feasibility, acceptability, and preliminary efficacy of a telehealth intervention (Symptom\u2010Targeted Randomized Intervention for Distress and Adherence to Adjuvant Endocrine Therapy [STRIDE]) for patients taking AET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2019 to June 2021, 100 patients reporting difficulty with AET were randomly assigned to either STRIDE or a medication monitoring (MedMon) control group. STRIDE included six weekly small\u2010group videoconferencing sessions and two individual calls. We defined feasibility as having &gt;50% of eligible patients enroll, &gt;70% complete the 12\u2010week assessment, and\u2009&gt;\u200970% of STRIDE patients complete \u22654\/6 sessions. We monitored adherence with the Medication Event Monitoring System Caps (MEMS Caps). At baseline and 12\u2010 and 24\u2010weeks after baseline, patients self\u2010reported adherence (Medication Adherence Report Scale), AET satisfaction (Cancer Therapy Satisfaction Questionnaire), symptom distress (Breast Cancer Prevention Trial\u2010Symptom Checklist), self\u2010management of symptoms (Self\u2010efficacy for Symptom Management\u2010AET), coping (Measure of Current Status), quality of life (QOL; Functional Assessment of Cancer Therapy\u2010Breast), and mood (Hospital Anxiety and Depression Scale). We used linear mixed effects models to assess the effect of STRIDE on longitudinal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 70.9% (100\/141) of eligible patients; 92% completed the 12\u2010week assessment, and 86% completed \u22654\/6 STRIDE sessions. Compared with MedMon, STRIDE patients reported less symptom distress (B[difference]\u00a0=\u00a0\u22121.91; 95% CI, \u22123.29 to \u22120.52; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) and better self\u2010management of AET symptoms, coping, QOL, and mood. We did not observe significant differences in AET satisfaction or adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STRIDE is feasible and acceptable, showing promise for improving outcomes in patients taking AET after breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Patients taking adjuvant endocrine therapy (AET) after breast cancer may face challenges while following their treatment regimen.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In this randomized controlled trial of 100 patients taking AET, a brief, small\u2010group virtual intervention (STRIDE) was well\u2010received by patients and led to improvements in how upset patients were due to symptoms, how confident they were in managing symptoms, and how well they could cope with stress. Thus, STRIDE is a promising intervention and should be tested in future multi\u2010site trials.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34409","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T08:25:25Z","timestamp":1659601525000},"page":"3541-3551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A telehealth intervention for symptom management, distress, and adherence to adjuvant endocrine therapy: A randomized controlled trial"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-624X","authenticated-orcid":false,"given":"Jamie M.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Post","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katina","family":"Massad","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora K.","family":"Horick","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cohn","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea S.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Clara","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-0873","authenticated-orcid":false,"given":"Michael H.","family":"Antoni","sequence":"additional","affiliation":[{"name":"University of Miami  Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Safren","sequence":"additional","affiliation":[{"name":"University of Miami  Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-4824","authenticated-orcid":false,"given":"Ann H.","family":"Partridge","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Peppercorn","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-264X","authenticated-orcid":false,"given":"Elyse R.","family":"Park","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5921","authenticated-orcid":false,"given":"Jennifer S.","family":"Temel","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-4076","authenticated-orcid":false,"given":"Joseph A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Cancer Society. 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