{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:47:53Z","timestamp":1772552873673,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201911015"],"award-info":[{"award-number":["SZSM201911015"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974492"],"award-info":[{"award-number":["81974492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The participation and results for liver cancer screening are rarely reported. The aim of this study was to determine the participation rates and factors affecting participation rates as well as to report the detection rate for liver cancer in an organized screening program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The organized screening program for liver cancer was conducted in 12 rural sites. The risk of developing liver cancer was initially evaluated for each participant. High\u2010risk individuals were offered \u03b1\u2010fetoprotein measurement and ultrasonography examination. Potential risk factors associated with the participation rate were screened by fitted generalized linear mixed logistic regression models through reporting odds ratios (ORs) with 95% CIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 358,662 eligible participants completed the basic surveys, and 54,745 were evaluated to be at high risk of liver cancer. Of these high\u2010risk individuals, 40,543 accepted the screening services. Determinants of participation for screening behavior included older age, being female, being positive for hepatitis B surface antigen, having a family history of liver cancer, chronic depression, and low income. The detection rate for liver cancer was estimated to be 0.41% (95% CI, 0.35\u20130.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study reported several significant factors associated with the screening behaviors for liver cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Participation rate and results for liver cancer screening in rural areas are rarely reported.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The determinants associated with adherence rates and early detection rate of liver cancer in an organized screening program for liver cancer were assessed.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>A possible positive correlation between the participation rates and the early detection rate was observed among attendees of screening. These new finds could be beneficial to increasing the participation rate of screening.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34418","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:00:19Z","timestamp":1661227219000},"page":"3653-3662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of the compliance, influencing factors, and yielding results of liver cancer screening in a high\u2010risk population: A cross\u2010sectional study"],"prefix":"10.1002","volume":"128","author":[{"given":"Maomao","family":"Cao","sequence":"first","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-9758","authenticated-orcid":false,"given":"Dianqin","family":"Sun","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"He","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Yan","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiu","family":"Zha","sequence":"additional","affiliation":[{"name":"Institute of Chronic Non\u2010communicable Diseases Prevention and Control Anhui Provincial Center for Disease Control and Prevention  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department for Chronic Non\u2010communicable Diseases Control Jiangsu Provincial Center for Disease Control and Prevention (Public health research institute of Jiangsu Province)  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department for Chronic Non\u2010communicable Diseases Control Jiangsu Provincial Center for Disease Control and Prevention (Public health research institute of Jiangsu Province)  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Preventive Management Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Preventive Management Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaokai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Disease Prevention The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Disease Prevention The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changfa","family":"Xia","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-092X","authenticated-orcid":false,"given":"Ji","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Shenzhen Center for Chronic Disease Control  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-1884","authenticated-orcid":false,"given":"Wanqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Office of Cancer Screening National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College\/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J","year":"2020","journal-title":"Lyon, France: International Agency for Research on Cancer"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2022.02.002"},{"key":"e_1_2_9_4_1","first-page":"532","article-title":"Consensus on the secondary prevention for primary liver cancer","volume":"37","author":"Chinese Society of Hepatology, Chinese Medical Association","year":"2021","journal-title":"J Clin Hepatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4417"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30398-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0552-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26703"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00373"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2019.0140"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.04.003"},{"key":"e_1_2_9_15_1","first-page":"1","article-title":"Preliminary analysis of cancer screening program in urban China from 2013 to 2017","volume":"29","author":"Chen W","year":"2020","journal-title":"China Cancer"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000916"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2021.05.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.04.11"},{"key":"e_1_2_9_19_1","unstructured":"WeirCB JanA.BMI classification percentile and cut off points. Updated June29 2021. Accessed March 19 2022.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541070\/"},{"key":"e_1_2_9_20_1","first-page":"322","volume-title":"Clinical Guidelines for Diagnosis and Treatment of Cancers","author":"Chinese Medical Association","year":"2005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S107370"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26944"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-011-1952-x"},{"key":"e_1_2_9_24_1","first-page":"1305","article-title":"Liver cancer screening in Korea: a report on the 2008 National Cancer Screening Programme","volume":"11","author":"Lee EH","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_9_25_1","first-page":"233","article-title":"Compliance rate and impact factor analysis of liver cancer screening in urban areas of Henan Province","volume":"43","author":"Guo LW","year":"2021","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3180381560"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.03.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000557"},{"key":"e_1_2_9_29_1","unstructured":"American Cancer Society. Liver Cancer Survival Rates. Accessed January 19 2022.https:\/\/www.cancer.org\/cancer\/liver\u2010cancer\/detection\u2010diagnosis\u2010staging\/survival\u2010rates.html"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.06.018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1258\/096914103771773320"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.34418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.34418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:08:49Z","timestamp":1760278129000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.34418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":30,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,10,15]]}},"alternative-id":["10.1002\/cncr.34418"],"URL":"https:\/\/doi.org\/10.1002\/cncr.34418","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"assertion":[{"value":"2022-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}