{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:46:07Z","timestamp":1764873967154,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99CA256216","P30 CA016672"],"award-info":[{"award-number":["K99CA256216","P30 CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Use of surveillance mammography and magnetic resonance imaging (MRI) has been understudied among women with variant of uncertain significance (VUS) compared to pathogenic and likely pathogenic variants (P\/LP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from two cancer settings, we calculated use of risk\u2010reducing mastectomy (RRM) and surveillance during each 13\u2010month span after genetic testing up to 6\u2009years afterwards for a cohort of genetically elevated risk women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 889 women, VUS carriers were less likely to undergo RRM compared to those with P\/LP (hazard ratio [HR], 0.17; <jats:italic>p<\/jats:italic>\u00a0=\u00a0&lt;.001) and high\u2010risk women were more likely to undergo RRM than average\u2010risk women (HR, 3.91; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Longitudinally, surveillance use among unaffected women decreased from 49.8% in the first year to 31.2% in the sixth year after genetic testing. In comparison, a greater proportion of women with a personal history of breast cancer underwent surveillance, which increased from 59.3% in the first year to 63.6% in the sixth year after genetic testing. Mammography rates did not differ between women with P\/LP and VUS within the first 13\u2009months after genetic testing and up to 4\u2009years afterward. Over the first 4\u2009years after genetic testing, women with VUS were less likely to undergo annual MRIs compared to P\/LP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The authors found that VUS, whether in high or moderate penetrance breast cancer susceptibility genes, was associated with lower use of annual breast MRI compared to P\/LP variants and equivalent use of annual mammography. These results add important evidence regarding VUS\u2010related breast surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34429","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T03:40:07Z","timestamp":1661226007000},"page":"3709-3717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of breast surveillance between women with pathogenic variants and variants of uncertain significance in breast cancer susceptibility genes"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-3833","authenticated-orcid":false,"given":"Sukh","family":"Makhnoon","sequence":"first","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minxing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Levin","sequence":"additional","affiliation":[{"name":"William G. Rohrer Cancer Genetics Program, Division of Hematology and Medical Oncology MD Anderson Cancer Center at Cooper University Health Care  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Ensinger","sequence":"additional","affiliation":[{"name":"OhioHealth Cancer Genetics Program OhioHealth  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin D.","family":"Mattie","sequence":"additional","affiliation":[{"name":"William G. Rohrer Cancer Genetics Program, Division of Hematology and Medical Oncology MD Anderson Cancer Center at Cooper University Health Care  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Generosa","family":"Grana","sequence":"additional","affiliation":[{"name":"William G. Rohrer Cancer Genetics Program, Division of Hematology and Medical Oncology MD Anderson Cancer Center at Cooper University Health Care  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-376X","authenticated-orcid":false,"given":"Sanjay","family":"Shete","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention and Population Sciences The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5475-8509","authenticated-orcid":false,"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[{"name":"Breast Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000159902.34833.26"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.7001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025794629878"},{"issue":"10","key":"e_1_2_9_6_1","first-page":"1115","article-title":"Utilization of breast cancer screening in a clinically based sample of women after BRCA1\/2 testing","volume":"11","author":"Peshkin BN","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-016-9981-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JMP-180016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.48"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07982-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13966"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1754"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38613"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00999"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9242-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05250-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2816-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.1209"},{"key":"e_1_2_9_19_1","article-title":"Patients' medical and psychosocial experiences after detection of a CDH1 variant with multigene panel testing. 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