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Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding biological differences between different racial groups of human papillomavirus (HPV)\u2010associated oropharyngeal squamous cell carcinoma (OPSCC) patients, who have differences in terms of incidence, survival, and tumor morphology, can facilitate accurate prognostic biomarkers, which can help develop personalized treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study evaluated whether there were morphologic differences between HPV\u2010associated tumors from Black and White patients in terms of multinucleation index (MuNI), an image analysis\u2010derived metric that measures density of multinucleated tumor cells within epithelial regions on hematoxylin\u2013eosin images and previously has been prognostic in HPV\u2010associated OPSCC patients. In this study, the authors specifically evaluated whether the same MuNI cutoff that was prognostic of overall survival (OS) and disease\u2010free survival in their previous study, T<jats:sub>TR<\/jats:sub>, is valid for Black and White patients, separately. We also evaluated population\u2010specific cutoffs, T<jats:sub>B<\/jats:sub> for Blacks and T<jats:sub>W<\/jats:sub> for Whites, for risk stratification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MuNI was statistically significantly different between Black (mean, 3.88e\u20134; median, 3.67e\u201304) and White patients (mean, 3.36e\u201304; median, 2.99e\u201304), with <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0078. Using T<jats:sub>TR<\/jats:sub>, MuNI was prognostic of OS in the entire population with hazard ratio (HR) of 1.71 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002; 95% confidence interval [CI], 1.21\u20132.43) and in White patients with HR of 1.72 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005; 95% CI, 1.18\u20132.51). Population\u2010specific cutoff, T<jats:sub>W<\/jats:sub>, yielded improved HR of 1.77 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003; 95% CI, 1.21\u20132.58) for White patients, whereas T<jats:sub>B<\/jats:sub> did not improve risk\u2010stratification in Black patients with HR of 0.6 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.3; HR, 0.6; 95% CI, 0.2\u20131.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histological difference between White and Black patient tumors in terms of multinucleated tumor cells suggests the need for considering population\u2010specific prognostic biomarkers for personalized risk stratification strategies for HPV\u2010associated OPSCC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34446","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T10:25:14Z","timestamp":1662459914000},"page":"3831-3842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus\u2010associated oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-2226","authenticated-orcid":false,"given":"Can F.","family":"Koyuncu","sequence":"first","affiliation":[{"name":"Wallace H. 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