{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:18:44Z","timestamp":1779887924086,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Both mismatched unrelated donor (MMUD) and haploidentical (haplo) transplantation are valid options in patients with high\u2010risk acute lymphoblastic leukemia (ALL) lacking a matched donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study compared the outcomes of adult patients with ALL in complete remission (CR) who underwent 9\/10\u2009MMUD versus haplo transplantation with posttransplant cyclophosphamide (PTCy) as graft\u2010vs\u2010host disease (GVHD) prophylaxis in 2010\u20132020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 781 patients (MMUD, 103; haplo, 678). The median age was 40 (19\u201373) and 38 (18\u201375) years, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u2009.51). The most frequent immunosuppression agents added to PTCy were mycophenolate mofetil (MMF)\/cyclosporine A and MMF\/tacrolimus. In vivo T\u2010cell depletion (anti\u2010thymocyte globulin) was administered to 21% and 8% of the transplants, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001). Neutrophil (absolute neutrophil count &gt;0.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) recovery was achieved in 97.1% versus 96.7% versus (<jats:italic>p<\/jats:italic>\u00a0=\u20091) in MMUD and haplo, respectively. Nonrelapse mortality and relapse incidence were not significantly different between MMUD and haplo, hazard ratio (HR)\u00a0=\u00a01.45 (95% confidence interval [CI], 0.81\u20132.62; <jats:italic>p<\/jats:italic>\u00a0=\u2009.21) and HR\u00a0=\u00a00.81 (95% CI, 0.52\u20131.28, <jats:italic>p<\/jats:italic>\u00a0=\u2009.38), respectively. HRs for leukemia\u2010free survival, overall survival, and GVHD\u2010free, relapse\u2010free survival were respectively, HR\u00a0=\u00a01.05 (95% CI, 0.73\u20131.50, <jats:italic>p<\/jats:italic>\u00a0=\u2009.8), HR\u00a0=\u00a01.17 (95% CI, 0.77\u20131.76, <jats:italic>p<\/jats:italic>\u00a0=\u2009.46), and HR\u00a0=\u00a01.07 (95% CI, 0.78\u20131.46, <jats:italic>p<\/jats:italic>\u00a0=\u2009.7) for haplo compared to MMUD. Acute (a)GVHD grade 2\u20134 was significantly higher with haplo, HR\u00a0=\u00a01.73 (95% CI, 1.08\u20132.76, <jats:italic>p<\/jats:italic>\u00a0=\u2009.023), whereas aGVHD grade 3\u20134 and chronic GVHD did not differ significantly between the two transplant groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes of MMUD and haplo transplants with PTCy\u2010based GVHD prophylaxis for ALL patients in CR are similar, apart from a higher incidence of aGVHD with haplo transplants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34452","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T02:09:51Z","timestamp":1663294191000},"page":"3959-3968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Posttransplant cyclophosphamide\u2010based anti\u2013graft\u2010vs\u2010host disease prophylaxis in patients with acute lymphoblastic leukemia treated in complete remission with allogeneic hematopoietic cell transplantation from human leukocyte antigen\u2010mismatched unrelated donors versus haploidentical donors: A study on behalf of the <scp>ALWP<\/scp> of the <scp>EBMT<\/scp>"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-1265","authenticated-orcid":false,"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM UMR\u2010S 938, CRSA, Service d'h\u00e9matologie et Th\u00e9rapie Cellulaire, AP\u2010HP, H\u00f4pital Saint\u2010Antoine  Paris France"},{"name":"European Society for Blood and Marrow Transplantation Paris Study Office\/CEREST\u2010TC  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"Arat","sequence":"additional","affiliation":[{"name":"Istanbul Florence Nightingale Hospital HSCT Unit  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Rem\u00e9nyi","sequence":"additional","affiliation":[{"name":"D\u00e9l\u2010pesti Centrumk\u00f3rh\u00e1z\u2010Orsz\u00e1gos Hematol\u00f3giai\u00e9s Infektol\u00f3giai Int\u00e9zet Department of Haematology and Stem Cell Transplant  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yener","family":"Koc","sequence":"additional","affiliation":[{"name":"Medicana International Hospital Istanbul Bone MarrowTransplant Unit  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation and Therapie Cellulaire Centre de Recherche en Canc\u00e9rologie de Marseille, Institut Paoli Calmettes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Angelucci","sequence":"additional","affiliation":[{"name":"Ospedale San Martino Department of Haematology II  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vydra","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Servicio de Hematolog\u00eda  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Kulagin","sequence":"additional","affiliation":[{"name":"First State Pavlov Medical University of St. Petersburg Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Hopital St. Louis, Department of Hematology\u2010BMT  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hospital Clinic, Department of Hematology Institute of Hematology and Oncology  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sica","sequence":"additional","affiliation":[{"name":"Universita Cattolica S. 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