{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:14:30Z","timestamp":1782249270173,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study reports the oncological and functional outcomes in men with localized prostate cancer (Pca) who were treated with primary whole gland cryoablation (WGC) of the prostate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors retrospectively reviewed their prospectively collected cryosurgery database between January 2002 and September 2019 for men who were treated with WGC of the prostate at a tertiary referral center. Primary outcome includes biochemical recurrence\u2010free survival (BRFS). Secondary outcomes include failure\u2010free survival (FFS), metastasis\u2010free survival (MFS) and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 260 men were included in the study. Men having had prior treatment for Pca were excluded. Median follow\u2010up was 107\u2009months (interquartile range [IQR], 68.3\u2013132.5\u2009months). BRFS, FFS, and MFS at 10\u2009years were 84%, 66%, and 96%, respectively. High risk D'Amico classification was associated with a lower BRFS and FFS on multivariable analysis. No patient had any Pca\u2010related death during follow\u2010up. American Urological Association symptoms score and bother index were unchanged following cryoablation. Median International Index of Erectile Function score precryoablation and post\u2010cryoablation was 7 (IQR, 3\u201311) and 1 (IQR, 1\u20135), respectively. Stress urinary incontinence, defined as requiring any protective pads only occurred in five patients (2%). No patient developed a fistula. Grade\u2009&gt;\u20092 Clavien\u2010Dindo adverse events occurred in six (2.3%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WGC of the prostate can achieve excellent oncological and functional outcomes in men with localized Pca at the 10\u2010year mark. Primary WGC may be a good option for men who desire to preserve urinary continence and have an excellent oncologic outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Primary whole gland cryoablation is an alternative treatment option to radical prostatectomy and radiotherapy for men with organ\u2010confined prostate cancer.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Patients had excellent cancer outcomes 1\u2009years after whole gland cryoablation, and patients with PSA nadir 0.1\u2009ng\/ml or lower after treatment were less likely to have disease recurrence.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34458","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T11:49:15Z","timestamp":1663242555000},"page":"3824-3830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Oncological and functional outcomes of men undergoing primary whole gland cryoablation of the prostate: A 20\u2010year experience"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-781X","authenticated-orcid":false,"given":"Wei Phin","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"},{"name":"Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Urology New York University Langone Health  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinath","family":"Kotamarti","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Chen","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Mahle","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohith","family":"Arcot","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"},{"name":"H. Lee Moffitt Cancer Center &amp; Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-442X","authenticated-orcid":false,"given":"Alexandria","family":"Ayala","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Michael","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-774X","authenticated-orcid":false,"given":"Denis","family":"Seguier","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Polascik","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"372","article-title":"Cryosurgical treatment of the prostate","volume":"3","author":"Gonder MJ","year":"1966","journal-title":"Invest Urol"},{"key":"e_1_2_8_3_1","unstructured":"National Comprehensive Cancer Network. 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