{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:32:47Z","timestamp":1780360367438,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited evidence supports the omission of routine bone marrow (BM) examination (biopsy and aspiration) in patients with nasal\u2010type extranodal NK\/T\u2010cell lymphoma (ENKTCL). This study was aimed at assessing whether BM examination provides valuable information for positron emission tomography\/computed tomography (PET\/CT)\u2013based staging in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patients newly diagnosed with ENKTCL who underwent initial staging with both PET\/CT and BM examination between 2013 and 2020 were retrospectively identified in two Chinese institutions. Overall, 742 patients were included; the BM examination was positive in 67 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with BM biopsy alone, the combination of BM biopsy and aspiration assessment did not afford any additional diagnostic value. No patient with a positive BM biopsy was found to have early\u2010stage disease by PET\/CT. BM biopsy or PET\/CT led to upstaging from stage III to IV as a result of BM involvement in 21 patients. In 135 patients with distant organ involvement, BM involvement was associated with worse overall survival (OS) and progression\u2010free survival (PFS) compared with the corresponding durations in patients without BM involvement (2\u2010year OS: 35.9% vs. 60.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001; PFS: 26% vs. 40.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). No difference in survival was noted between groups judged positive based on PET\/CT and BM biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with aspiration, BM biopsy led to the detection of more BM lesions. Baseline PET\/CT can be safely used to exclude BM involvement in early\u2010stage disease. Overall, routine BM examination affords diagnostic or prognostic value over PET\/CT in patients with advanced\u2010stage nasal\u2010type ENKTCL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34473","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T11:29:34Z","timestamp":1664623774000},"page":"3943-3950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The value of routine bone marrow examination in patients with extranodal NK\/T\u2010cell lymphoma staged with PET\/CT"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-9972","authenticated-orcid":false,"given":"Yong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University) Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies)  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Zhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University) Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies)  Fuzhou 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