{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:59:36Z","timestamp":1792699176682,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pruritus is one of the most common and challenging side effects of epidermal growth factor receptor\u2010tyrosine kinase inhibitors (EGFR\u2010TKIs) and has impaired patients' quality of life and treatment compliance. Our study evaluated the efficacy and safety of aprepitant in managing EGFR\u2010TKIs\u2013related pruritus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled study was conducted between December 2016 and August 2020 in China. Patients were eligible if they were 18\u00a0years or older and had histologically confirmed locally advanced or metastatic non\u2013small cell lung cancer (NSCLC) with first onset of moderate to severe pruritus during EGFR\u2010TKI treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 130 eligible patients were randomly assigned to aprepitant (<jats:italic>n<\/jats:italic>\u00a0=\u00a065) or desloratadine (<jats:italic>n<\/jats:italic>\u00a0=\u00a065) groups. The median (interquartile range [Q1, Q3]) age was 63 (54, 70) years, and 79 (60.8%) were women. Mean visual analog scale scores at baseline were 6.35 (95% confidence interval [CI], 5.89\u20136.82) in the aprepitant group and 5.94 (95% CI, 5.56\u20136.32) in the desloratadine group. After 1\u00a0week of treatment, 33 (53.2%) patients responded to aprepitant, which was significantly higher than that of 14 (23.7%) patients responded to desloratadine (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Moreover, patients in the aprepitant group had a significantly shorter response time than patients in the desloratadine group (mean [days], 13.39 [95% CI, 11.08\u201315.70] vs. 16.67 [95% CI, 14.19\u201319.13], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). The most frequent drug\u2010related adverse events in aprepitant group and desloratadine were constipation and dry mouth, and all adverse events were grade 1\u20132.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the authors\u2019 knowledge, this is the first study to prospectively present that aprepitant elicited a better and faster response and mild toxicity for managing EGFR\u2010TKI induced pruritus than desloratadine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>ClinicalTrials.gov Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00268476\">NCT02646020<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34474","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T10:04:42Z","timestamp":1664964282000},"page":"3969-3976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of aprepitant versus desloratadine for EGFR\u2010TKI\u2010induced pruritus: A randomized phase 2 clinical trial"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-3055","authenticated-orcid":false,"given":"Ting","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine  Guangzhou Guangdong 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