{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:13:33Z","timestamp":1791893613013,"version":"4.3.4"},"reference-count":110,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate to provide annual updates on cancer occurrence and trends in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on new cancer diagnoses during 2001\u20132018 were obtained from the North American Association of Central Cancer Registries\u2019 Cancer in North America Incidence file, which is comprised of data from Centers for Disease Control and Prevention\u2010funded and National Cancer Institute\u2010funded, population\u2010based cancer registry programs. Data on cancer deaths during 2001\u20132019 were obtained from the National Center for Health Statistics' National Vital Statistics System. Five\u2010year average incidence and death rates along with trends for all cancers combined and for the leading cancer types are reported by sex, racial\/ethnic group, and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall cancer incidence rates were 497 per 100,000 among males (ranging from 306 among Asian\/Pacific Islander males to 544 among Black males) and 431 per 100,000 among females (ranging from 309 among Asian\/Pacific Islander females to 473 among American Indian\/Alaska Native females) during 2014\u20132018. The trend during the corresponding period was stable among males and increased 0.2% on average per year among females, with differing trends by sex, racial\/ethnic group, and cancer type. Among males, incidence rates increased for three cancers (including pancreas and kidney), were stable for seven cancers (including prostate), and decreased for eight (including lung and larynx) of the 18 most common cancers considered in this analysis. Among females, incidence rates increased for seven cancers (including melanoma, liver, and breast), were stable for four cancers (including uterus), and decreased for seven (including thyroid and ovary) of the 18 most common cancers. Overall cancer death rates decreased by 2.3% per year among males and by 1.9% per year among females during 2015\u20132019, with the sex\u2010specific declining trend reflected in every major racial\/ethnic group. During 2015\u20132019, death rates decreased for 11 of the 19 most common cancers among males and for 14 of the 20 most common cancers among females, with the steepest declines (&gt;4% per year) reported for lung cancer and melanoma. Five\u2010year survival for adenocarcinoma and neuroendocrine pancreatic cancer improved between 2001 and 2018; however, overall incidence (2001\u20132018) and mortality (2001\u20132019) continued to increase for this site. Among children (younger than 15\u00a0years), recent trends were stable for incidence and decreased for mortality; and among, adolescents and young adults (aged 15\u201339\u00a0years), recent trends increased for incidence and declined for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer death rates continued to decline overall, for children, and for adolescents and young adults, and treatment advances have led to accelerated declines in death rates for several sites, such as lung and melanoma. The increases in incidence rates for several common cancers in part reflect changes in risk factors, screening test use, and diagnostic practice. Racial\/ethnic differences exist in cancer incidence and mortality, highlighting the need to understand and address inequities. Population\u2010based incidence and mortality data inform prevention, early detection, and treatment efforts to help reduce the cancer burden in the United States.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.34479","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T10:01:41Z","timestamp":1666864901000},"page":"4251-4284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":530,"title":["Annual report to the nation on the status of cancer, part 1: National cancer statistics"],"prefix":"10.1002","volume":"128","author":[{"given":"Kathleen A.","family":"Cronin","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-8313","authenticated-orcid":false,"given":"Susan","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert U.","family":"Firth","sequence":"additional","affiliation":[{"name":"Information Management Services, Inc  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-5997","authenticated-orcid":false,"given":"Hyuna","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Surveillance and Health Equity Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-306X","authenticated-orcid":false,"given":"S. Jane","family":"Henley","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recinda L.","family":"Sherman","sequence":"additional","affiliation":[{"name":"North American Association of Central Cancer Registries  Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Surveillance and Health Equity Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Anderson","sequence":"additional","affiliation":[{"name":"National Center for Health Statistics, Centers for Disease Control and Prevention  Hyattsville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy A.","family":"Kohler","sequence":"additional","affiliation":[{"name":"North American Association of Central Cancer Registries  Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0819","authenticated-orcid":false,"given":"Vicki B.","family":"Benard","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-9519","authenticated-orcid":false,"given":"Serban","family":"Negoita","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Wiggins","sequence":"additional","affiliation":[{"name":"New Mexico Tumor Registry, University of New Mexico Comprehensive Cancer Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Cance","sequence":"additional","affiliation":[{"name":"American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-4111","authenticated-orcid":false,"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Department of Surveillance and Health Equity Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Cancer in North America: 2014\u20102018. 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