{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:45:03Z","timestamp":1791567903075,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The need for axillary dissection (AD) is declining, but it is still essential for many patients with nodal involvement who risk developing breast\u2010cancer\u2013related lymphedema (BCRL) with lifelong consequences. Previous nonrandomized studies found axillary reverse mapping and selective axillary dissection (ARM\u2010SAD) a safe and feasible way to preserve the arm's lymphatic drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present two\u2010arm prospective randomized clinical trial was held at a single comprehensive cancer center to ascertain whether ARM\u2010SAD can reduce the risk of BCRL, compared with standard AD, in patients with node\u2010positive breast cancer. Whatever the type of breast surgery or adjuvant treatments planned, 130 patients with nodal involvement met our inclusion criteria: 65 were randomized for AD and 65 for ARM\u2010SAD. Twelve months after surgery, a physiatrist assessed patients for BCRL and calculated the excess volume of the operated arm. Lymphoscintigraphy was used to assess drainage impairment. Self\u2010reports of any impairment were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference in the incidence of BCRL between the two groups was 21% (95% CI, 3\u201037; p\u00a0=\u00a0.03). A significantly lower rate of BCRL after ARM\u2010SAD was confirmed by a multimodal analysis that included the physiatrist's findings, excess arm volume, and lymphoscintigraphic findings, but this was not matched by a significant difference in patients' self\u2010reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings encourage a change of surgical approach when AD is still warranted. ARM\u2010SAD may be an alternative to standard AD to reduce the treatment\u2010related morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.34498","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T09:31:55Z","timestamp":1666171915000},"page":"4185-4193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Occurrence of breast\u2010cancer\u2013related lymphedema after reverse lymphatic mapping and selective axillary dissection versus standard surgical treatment of axilla: A two\u2010arm randomized clinical trial"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-1665","authenticated-orcid":false,"given":"Massimiliano","family":"Gennaro","sequence":"first","affiliation":[{"name":"Breast Surgery Unit Fondazione IRCCS Istituto Nazionale Tumori  Milan 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